Assessment of Oral Bioaccessibility of Organochlorine Pesticides in Soil   Using an In Vitro Gastrointestinal Model

doi:10.1021/es900188c

CORC > 北京大学 > 城市与环境学院

	Assessment of Oral Bioaccessibility of Organochlorine Pesticides in Soil Using an In Vitro Gastrointestinal Model
	Tao, Shu ; Lu, Yan ; Zhang, Diyu ; Yang, Yifeng ; Yang, Yu ; Lu, Xiaoxia ; Sai, Daojian
刊名	environmental science technology
	2009
关键词	POLYCYCLIC AROMATIC-HYDROCARBONS CONTAMINATED SOIL DIGESTIVE FLUID BIOAVAILABILITY MOBILIZATION VEGETABLES SEDIMENT RESIDUES LINDANE TRACT
DOI	10.1021/es900188c
英文摘要	A static in vitro gastrointestinal model was used to investigate the oral bioaccessibility of organochlorine pesticides (OCPs) including hexachlorocyclohexane isomers (HCHs) and dichlorodiphenyltrichloroethane and metabolites in contaminated soils with different organic matter contents. A key hypothesis tested was that a fraction of the mobilized contaminants is sorbed on the solid after digestion, and this fraction could be desorbed and become bioaccessible in the intestinal tract due to absorption of the dissolved fraction by the small intestine. The bioaccessibility would be underestimated if the sorbed fracton was separated from the fluid by centrifugation or filtration in an in vitro test. In our experiment, a procedure using multiple fluid-to-solid ratios was developed to characterize the sorption. It was found that 8-38% of the mobilized OCPs were sorbed on the residue and remained in the solid phase after the separation. Taking into consideration the sorbed fraction, the measured bioaccessibilities of the OCPs varied from 4% to 97% depending on the-properties of the soils and the compounds. The enanbomeric ratios of chiral compounds studied were also determined to distinguish biotic (enzymatic) and abiotic (chemical extraction) processes in the in vitro digestion model. It was found that although alpha-HCH in the raw soils was racemic, (+)-alpha-HCH was enriched in the gastric digestive fluid but depleted in the intestinal digestive fluid.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000266968500049&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Environmental; Environmental Sciences; SCI(E); EI; PubMed; 32; ARTICLE; 12; 4524-4529; 43
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/160728]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Tao, Shu,Lu, Yan,Zhang, Diyu,et al. Assessment of Oral Bioaccessibility of Organochlorine Pesticides in Soil Using an In Vitro Gastrointestinal Model[J]. environmental science technology,2009.
APA	Tao, Shu.,Lu, Yan.,Zhang, Diyu.,Yang, Yifeng.,Yang, Yu.,...&Sai, Daojian.(2009).Assessment of Oral Bioaccessibility of Organochlorine Pesticides in Soil Using an In Vitro Gastrointestinal Model.environmental science technology.
MLA	Tao, Shu,et al."Assessment of Oral Bioaccessibility of Organochlorine Pesticides in Soil Using an In Vitro Gastrointestinal Model".environmental science technology (2009).