Accumulation Dynamics of Chlordanes and Their Enantiomers in Cockerels   (Gallus gallus) after Oral Exposure

doi:10.1021/es201629p

CORC > 北京大学 > 城市与环境学院

	Accumulation Dynamics of Chlordanes and Their Enantiomers in Cockerels (Gallus gallus) after Oral Exposure
	Lu, Zhijiang ; Xue, Miao ; Shen, Guofeng ; Li, Kaiyang ; Li, Xiqing ; Wang, Xilong ; Tao, Shu
刊名	environmental science technology
	2011
关键词	CHIRAL ORGANOCHLORINE COMPOUNDS RESOLUTION GAS-CHROMATOGRAPHY ALPHA-HEXACHLOROCYCLOHEXANE TECHNICAL CHLORDANE ENANTIOSELECTIVE DETERMINATION MASS-SPECTROMETRY TISSUES PESTICIDES CONTAMINANTS COMPONENTS
DOI	10.1021/es201629p
英文摘要	After a single oral exposure of technical chlordane, levels of cis-chlordane (CC), trans-chlordane (TC), heptachlor (HEP), heptachlorepoxide (HEPX), and oxychlordane (OXY) were determined in gastrointestinal residues, droppings, and various tissues of cockerels at times of 60, 120, 160, 200, 300, 500, 1000, and 2000 min. Over 98% of CC and TC were found to be bioaccessible; only 1.1% of CC and TC were directly excreted through droppings without further biotransformation. According to the single-compartment toxicokinetic modeling CC and TC shared similar absorption rates in the whole body while TC showed a slightly more rapid elimination rate, with a half-life of 13.4 h for CC and 12.5 h for TC. The metabolites HEPX and OXY appeared quickly in tissues 60 min after exposure and were mainly accumulated in fat and liver tissues. Concentrations of CC, TC, and HEP in cockerel tissues roughly followed the order as fat > intestine > skin > liver > brain > muscle > blood. Levels of CC, TC, and HEP in various tissues showed significant correlation with the lipid contents of the tissues (p < 0.05) for samples beginning 500 min after exposure. A multicompartment toxicokinetic model was developed to characterize the accumulation dynamics of CC and TC in the various tissues. All tissues of cockerels enantioselectively accumulated (-)-CC and (+)-TC, and fat, skin, and liver tissues showed a relatively stronger capacity of enantioenrichment The enantiomer fractions (EFs) of droppings remained nearly racemic at first but gradually decreased to less than 0.5 for CC and increased to more than 0.5 for TC, which could rule out enantioselective absorption and excretion of CC and TC in cockerels. The one-compartment toxicokinetic model was applied to the individual enantiomers of CC and TC. Different elimination rates but similar absorption rates were observed between the enantiomers for both CC and TC.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000294791200045&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Environmental; Environmental Sciences; SCI(E); EI; PubMed; 1; ARTICLE; 18; 7928-7935; 45
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/160658]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Lu, Zhijiang,Xue, Miao,Shen, Guofeng,et al. Accumulation Dynamics of Chlordanes and Their Enantiomers in Cockerels (Gallus gallus) after Oral Exposure[J]. environmental science technology,2011.
APA	Lu, Zhijiang.,Xue, Miao.,Shen, Guofeng.,Li, Kaiyang.,Li, Xiqing.,...&Tao, Shu.(2011).Accumulation Dynamics of Chlordanes and Their Enantiomers in Cockerels (Gallus gallus) after Oral Exposure.environmental science technology.
MLA	Lu, Zhijiang,et al."Accumulation Dynamics of Chlordanes and Their Enantiomers in Cockerels (Gallus gallus) after Oral Exposure".environmental science technology (2011).