Distribution is a Major Factor Affecting Bioaccumulation of   Decabrominated Diphenyl Ether: Chinese Sturgeon (Acipenser sinensis) as   an Example

doi:10.1021/es304926r

CORC > 北京大学 > 城市与环境学院

	Distribution is a Major Factor Affecting Bioaccumulation of Decabrominated Diphenyl Ether: Chinese Sturgeon (Acipenser sinensis) as an Example
	Wan, Yi ; Zhang, Kun ; Dong, Zhaomin ; Hu, Jianying
刊名	environmental science technology
	2013
关键词	BROMINATED FLAME RETARDANTS TROUT ONCORHYNCHUS-MYKISS DECABROMODIPHENYL ETHER RAINBOW-TROUT COMPENSATORY GROWTH ORGANIC POLLUTANTS MATERNAL TRANSFER BODY-COMPOSITION DIETARY UPTAKE FRESH-WATER
DOI	10.1021/es304926r
英文摘要	While decabromodiphenyl ether (BDE-209) has very low bioavailability and a rapid biotransformation rate, it exhibits high bioaccumulation in wildlife. To explore the bioaccumulation mechanism of BDE-209 in organisms, its toxicokinetic processes were investigated in Chinese sturgeons from the Yangtze River. Different from less brominated BDEs, lipids did not play an important role in the distribution of BDE-209 with relatively high concentrations detected in liver (54.5 +/- 3.3 ng/g wet weight (ww)), gills (47.4 +/- 2.9 ng/g ww), and intestine (41.9 +/- 3.0 ng/g ww), followed by stomach (21.9 +/- 9.0 ng/g ww), muscle (19.1 +/- 5.6 ng/g ww), heart (7.5 +/- 5.2 ng/g ww), gonad (6.8 +/- 4.9 ng/g ww), adipose (4.9 +/- 1.2 ng/g ww), and egg (2.8 +/- 2.3 ng/g ww). In vitro metabolism of BDE-209 by microsomal fractions of Chinese sturgeon found that BDE-209 was biotransformed rapidly with the rate constant (K) of 0.039 h(-1) in liver. BDE-126, BDE-154, BDE-188, BDE-184, BDE-183, BDE-202, BDE-201, and BDE-204/197 were observed as debrominated products of BDE-209 after incubation, and their formation rates were 0.026, 0.016, and 0.006 h(-1) for BDE-126 BDE-184, and BDE-154, respectively. The concentration ratios between heart and intestine for individual PBDEs suggested slow delivery of BDE-209 among tissues after absorption. A Bayesian hierarchical model was further developed to estimate partition coefficients in a physiologically based pharmacokinetic model of BDE-209 in Chinese sturgeon. The estimated partition coefficients between tissues and blood were higher than those of less brominated BDE or PCBs in various animals, suggesting that the low partition ratios from blood to tissues would lead to high bioaccumulation of BDE-209, especially in absorbing organs.; Engineering, Environmental; Environmental Sciences; SCI(E); EI; PubMed; 7; ARTICLE; 5; 2279-2286; 47
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/160615]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Wan, Yi,Zhang, Kun,Dong, Zhaomin,et al. Distribution is a Major Factor Affecting Bioaccumulation of Decabrominated Diphenyl Ether: Chinese Sturgeon (Acipenser sinensis) as an Example[J]. environmental science technology,2013.
APA	Wan, Yi,Zhang, Kun,Dong, Zhaomin,&Hu, Jianying.(2013).Distribution is a Major Factor Affecting Bioaccumulation of Decabrominated Diphenyl Ether: Chinese Sturgeon (Acipenser sinensis) as an Example.environmental science technology.
MLA	Wan, Yi,et al."Distribution is a Major Factor Affecting Bioaccumulation of Decabrominated Diphenyl Ether: Chinese Sturgeon (Acipenser sinensis) as an Example".environmental science technology (2013).