Isomer-Specific Accumulation of Perfluorooctanesulfonate from (N-Ethyl   perfluorooctanesulfonamido)ethanol-based Phosphate Diester in Japanese   Medaka (Oryzias latipes)

doi:10.1021/es404867w

CORC > 北京大学 > 城市与环境学院

	Isomer-Specific Accumulation of Perfluorooctanesulfonate from (N-Ethyl perfluorooctanesulfonamido)ethanol-based Phosphate Diester in Japanese Medaka (Oryzias latipes)
	Peng, Hui ; Zhang, Shiyi ; Sun, Jianxian ; Zhang, Zhong ; Giesy, John P. ; Hu, Jianying
刊名	environmental science technology
	2014
关键词	TROUT ONCORHYNCHUS-MYKISS SPRAGUE-DAWLEY RATS PERFLUORINATED COMPOUNDS LAKE-ONTARIO FOOD-WEB TISSUE DISTRIBUTION MASS-SPECTROMETRY MATERNAL TRANSFER HUMAN BLOOD SULFONATE
DOI	10.1021/es404867w
英文摘要	While (N-ethyl perfluorooctanesulfonamido)-ethanol (FOSE) -based phosphate diester (diSPAP) has been proposed as a candidate precursor of perfluorooctanesulfonate (PFOS), its potential biotransformation to PFOS has not been verified. Metabolism of diSPAP was investigated in Japanese medaka (Oryzias latipes) after exposure in water for 10 days, followed by 10 days of depuration. Branched isomers of diSPAP (B-diSPAP) were preferentially enriched in medaka exposed, to diSPAP, with the proportion of branched isomers (BF) ranging from 0.56 to 0.80, which was significantly greater than that in the water. to which. the medaka were exposed (0.36) (p < 0.001). This enrichment was due primarily to preferential uptake of B-diSPAP. PFOS together with perfluorooctanesulfonamide (PFOSA), N-ethyl perfluorooctanesulfonamide (NEtFOSA), 2-(perfluorooctanesulfonamido)acetic acid (FOSAA), NEtFOSAA, FOSE, and NEtFOSE were detected in medaka exposed to diSPAP, which indicated the potential for biotransformation of diSPAP to PFOS via multiple intermediates. Due to preferential metabolism of branched isomers, FOSAA and PFOSA exhibited greater BF values (>0.5) than those of NEtFOSA, NEtFOSAA, and NEtFOSE (<0.2). Such preferential metabolism of branched isomers along the primary pathway of metabolism and preferential accumulation of B-diSPAP led to enrichment of branched PFOS (B-PFOS) in medaka. Enrichment of B-PFOS was greater for 3-, 4-, and 5-perfluoromethyl PFOS (P3MPFOS, P4MPFOS, and P5MPFOS), for which values of BF were 0.58 +/- 0.07, 0.62 +/- 0.06, and 0.61 +/- 0.05 (day 6), respectively; these values are 5.8-, 7.8-, and 6.4-fold greater than those of technical. PFOS. This work provides evidence on the isomer-specific accumulation of PFOS from diSPAP and will be helpful to track indirect sources of PFOS in the future.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000330205000029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Environmental; Environmental Sciences; SCI(E); EI; PubMed; 4; ARTICLE; hujy@urban.pku.edu.cn; 2; 1058-1066; 48
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/160578]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Peng, Hui,Zhang, Shiyi,Sun, Jianxian,et al. Isomer-Specific Accumulation of Perfluorooctanesulfonate from (N-Ethyl perfluorooctanesulfonamido)ethanol-based Phosphate Diester in Japanese Medaka (Oryzias latipes)[J]. environmental science technology,2014.
APA	Peng, Hui,Zhang, Shiyi,Sun, Jianxian,Zhang, Zhong,Giesy, John P.,&Hu, Jianying.(2014).Isomer-Specific Accumulation of Perfluorooctanesulfonate from (N-Ethyl perfluorooctanesulfonamido)ethanol-based Phosphate Diester in Japanese Medaka (Oryzias latipes).environmental science technology.
MLA	Peng, Hui,et al."Isomer-Specific Accumulation of Perfluorooctanesulfonate from (N-Ethyl perfluorooctanesulfonamido)ethanol-based Phosphate Diester in Japanese Medaka (Oryzias latipes)".environmental science technology (2014).