Characteristics and cellular effects of ambient particulate matter from   Beijing

doi:10.1016/j.envpol.2014.04.008

CORC > 北京大学 > 城市与环境学院

	Characteristics and cellular effects of ambient particulate matter from Beijing
	Lu, Yan ; Su, Shu ; Jin, Wenjie ; Wang, Bin ; Li, Ning ; Shen, Huizhong ; Li, Wei ; Huang, Ye ; Chen, Han ; Zhang, Yanyan ; Chen, Yuanchen ; Lin, Nan ; Wang, Xilong ; Tao, Shu
刊名	environmental pollution
	2014
关键词	Particulate matter In vitro test Cytotoxicity Inflammatory effect DIESEL EXHAUST PARTICLES AIRWAY EPITHELIAL-CELLS OXIDATIVE STRESS IN-VITRO COARSE PARTICLES SIZE FRACTIONS REDOX ACTIVITY MEXICO-CITY POLLUTION FINE
DOI	10.1016/j.envpol.2014.04.008
英文摘要	In vitro tests using human adenocarcinomic alveolar epithelial cell line A549 and small mouse monocyte-macrophage cell line J774A.1 were conducted to test toxicity of six PM (particulate matter) samples from Beijing. The properties of the samples differ significantly. The production of inflammatory cytokine (TNF-alpha for J774A.1) and chemokine (IL-8 for A549) and the level of intracellular reactive oxygen species (ROS) were used as endpoints. There was a positive correlation between water soluble organic carbon and DTT-based redox activity. Both cell types produced increased levels of inflammatory mediators and had higher level of intracelllar ROS, indicating the presence of PM-induced inflammatory response and oxidative stress, which were dose-dependent and significantly different among the samples. The releases of IL-8 from A549 and TNF-alpha. from J774A.1 were significantly correlated to PM size, Zeta potential, endotoxin, major metals, and polycyclic aromatic hydrocarbons. No correlation between ROS and these properties was identified. (C) 2014 Elsevier Ltd. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000338605200009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Environmental Sciences; SCI(E); EI; PubMed; 4; ARTICLE; taos@pku.edu.cn; 63-69; 191
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/160558]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Lu, Yan,Su, Shu,Jin, Wenjie,et al. Characteristics and cellular effects of ambient particulate matter from Beijing[J]. environmental pollution,2014.
APA	Lu, Yan.,Su, Shu.,Jin, Wenjie.,Wang, Bin.,Li, Ning.,...&Tao, Shu.(2014).Characteristics and cellular effects of ambient particulate matter from Beijing.environmental pollution.
MLA	Lu, Yan,et al."Characteristics and cellular effects of ambient particulate matter from Beijing".environmental pollution (2014).