Bioacessibility of PAHs in Fuel Soot Assessed by an in Vitro Digestive   Model: Effect of Including an Absorptive Sink

doi:10.1021/es505898v

CORC > 北京大学 > 城市与环境学院

	Bioacessibility of PAHs in Fuel Soot Assessed by an in Vitro Digestive Model: Effect of Including an Absorptive Sink
	Zhang, Yanyan ; Pignatello, Joseph J. ; Tao, Shu ; Xing, Baoshan
刊名	environmental science technology
	2015
关键词	POLYCYCLIC AROMATIC-HYDROCARBONS PHYSIOLOGICALLY-BASED EXTRACTION BLACK CARBON POLYCHLORINATED-BIPHENYLS SOIL CONTAMINANTS ORGANIC-MATTER BIOACCESSIBILITY SORPTION SEDIMENTS EXPOSURE
DOI	10.1021/es505898v
英文摘要	Polycyclic aromatic hydrocarbons (PAHs) associated with soot or black carbon can enter the human digestive tract by unintentional ingestion of soil or other particles. This study investigated the bioaccessibility of 11 PAHs in a composite fuel soot sample using an in vitro digestive model that included silicone sheet as an absorptive sink during the small intestinal digestion stage. The sheet was meant to simulate the passive transfer of PAHs in lumen fluid across the small intestinal epithelium, which was postulated to promote desorption of labile PAHs from the soot by steepening the soot-fluid concentration gradient. We show that the presence of silicone sheet during a 4 h default digestion time significantly increased the apparent bioaccessible fraction (B-app, %), defined as the sum in the sheet and digestive fluid relative to the total PAH determined. The ability to increase B-app for most PAHs leveled off above a sheet-to-soot ratio of 2.0 g per 50 mg, indicating that the sheet is an effective absorptive sink and promotes desorption in the mentioned way. Enhancement of B-app by the sheet correlated positively with the octanol-water partition coefficient (K-ow), even though the partition coefficient of PAR between sheet and digestive fluid (which contains bile acid micelles) correlated negatively with K-ow. It was hypothesized that PAHs initially in the soot exist in labile and nonlabile states. The fraction of labile PAH still sorbed to the soot residue after digestion, and the maximum possible (limiting) bioaccessibility (B-lim) could be estimated by varying the sheet-to-soot ratio. We show conclusively that the increase in bioccessibility due to the presence of the sheet is accounted for by a corresponding decrease in fraction of labile PAH still sorbed to the soot. The B-lim ranged from 30.8 to 62.4%, independent of molecular size. The nonlabile fraction of individual PAHs (69.2-37.6% in this case) is therefore large and needs to be taken into account in risk assessment.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000351324400075&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Environmental; Environmental Sciences; SCI(E); EI; PubMed; 6; ARTICLE; Joseph.pignatello@ct.gov; 6; 3905-3912; 49
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/160517]
专题	城市与环境学院
推荐引用方式 GB/T 7714	Zhang, Yanyan,Pignatello, Joseph J.,Tao, Shu,et al. Bioacessibility of PAHs in Fuel Soot Assessed by an in Vitro Digestive Model: Effect of Including an Absorptive Sink[J]. environmental science technology,2015.
APA	Zhang, Yanyan,Pignatello, Joseph J.,Tao, Shu,&Xing, Baoshan.(2015).Bioacessibility of PAHs in Fuel Soot Assessed by an in Vitro Digestive Model: Effect of Including an Absorptive Sink.environmental science technology.
MLA	Zhang, Yanyan,et al."Bioacessibility of PAHs in Fuel Soot Assessed by an in Vitro Digestive Model: Effect of Including an Absorptive Sink".environmental science technology (2015).