Cue-independent memory impairment by reactivation-coupled interference   in human declarative memory

doi:10.1016/j.cognition.2016.06.015

CORC > 北京大学 > 生命科学学院

	Cue-independent memory impairment by reactivation-coupled interference in human declarative memory
	Zhu, Zijian ; Wang, Yingying ; Cao, Zhijun ; Chen, Biqing ; Cai, Huaqian ; Wu, Yanhong ; Rao, Yi
刊名	COGNITION
	2016
关键词	Declarative memory Interference Reactivation Reconsolidation RETRIEVAL-EXTINCTION PROCEDURE PROTEIN-SYNTHESIS FEAR MEMORY EPISODIC MEMORIES EXECUTIVE CONTROL RECONSOLIDATION MECHANISMS AMYGDALA DYNAMICS CONSOLIDATION
DOI	10.1016/j.cognition.2016.06.015
英文摘要	Memory is a dynamic process. While memory becomes increasingly resistant to interference after consolidation, a brief reactivation renders it unstable again. Previous studies have shown that interference, when applied upon reactivation, impairs the consolidated memory, presumably by disrupting the reconsolidation of the memory. However, attempts have failed in disrupting human declarative memory, raising a question about whether declarative memory becomes unstable upon reactivation. Here, we used a double-cue/one-target paradigm, which associated the same target with two different cues in initial memory formation. Only one cue/target association was later reactivated and treated with behavioral interference. Our results showed, for the first time, that reactivation-coupled interference caused cue-independent memory impairment that generalized to other cues associated with the memory. Critically, such memory impairment appeared immediately after interference, before the reconsolidation process was completed, suggesting that common manipulations of reactivation-coupled interference procedures might disrupt other processes in addition to the reconsolidation process in human declarative memory. (C) 2016 Published by Elsevier B.V.; National Natural Science Foundation of China [NSFC-31421003, NSFC-31371054]; National Social Science Foundation of China [SSFC-12AZD116]; [973-2015CB351800]; PubMed; SSCI; ARTICLE; wuyh@pku.edu.cn; yrao@pku.edu.cn; 125-134; 155
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/493525]
专题	生命科学学院心理与认知科学学院信息科学技术学院
推荐引用方式 GB/T 7714	Zhu, Zijian,Wang, Yingying,Cao, Zhijun,et al. Cue-independent memory impairment by reactivation-coupled interference in human declarative memory[J]. COGNITION,2016.
APA	Zhu, Zijian.,Wang, Yingying.,Cao, Zhijun.,Chen, Biqing.,Cai, Huaqian.,...&Rao, Yi.(2016).Cue-independent memory impairment by reactivation-coupled interference in human declarative memory.COGNITION.
MLA	Zhu, Zijian,et al."Cue-independent memory impairment by reactivation-coupled interference in human declarative memory".COGNITION (2016).