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	Antinociception induced by galanin in anterior cingulate cortex in rats with acute inflammation
	Zhang, Meng-Lin ; Fu, Feng-Hua ; Yu, Long-Chuan
刊名	NEUROSCIENCE LETTERS
	2017
关键词	Anterior cingulate cortex (ACC) Antinociception Galanin Galanin receptor 2 (Gal R2) Hindpaw withdrawal latency Acute inflammation CENTRAL-NERVOUS-SYSTEM PERIAQUEDUCTAL GREY NUCLEUS-ACCUMBENS NEUROPATHIC PAIN ARCUATE NUCLEUS MONONEUROPATHY INVOLVEMENT HYPOTHALAMUS RECEPTORS PEPTIDE
DOI	10.1016/j.neulet.2016.12.034
英文摘要	The present study was performed to explore the role of galanin in nociceptive modulation in anterior cingulate cortex (ACC) of rats with acute inflammation, and the changes in galanin and galanin receptor 2 (Gal R2) expressions in rats with acute inflammation. Intra-ACC injection of galanin induced antinociception in rats with acute inflammation, the antinociceptive effects induced by galanin were attenuated significantly by intra-ACC injection of the Gal R2 antagonist M871, indicating an involvement of Gal R2 in nociceptive modulation in ACC in rats with acute inflammation. Furthermore, we found that both the galanin mRNA expression and galanin content increased significantly in ACC in rats with acute inflammation than that in normal rats. Moreover, both the mRNA levels of Gal R2 and the content of Gal R2 in ACC increased significantly in rats with acute inflammation than that in normal rats. These results demonstrated that galanin induced antinociception in ACC in rats with acute inflammation. And there were changes in the expression of galanin and Gal R2 in rats with acute inflammation. (C) 2016 Elsevier Ireland Ltd. All rights reserved.; Foundation of Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong(Yantai University); Graduate Innovation Foundation of Yantai University; National Natural Science Foundation of China [NSFC 30870802, 81171043]; SCI(E); ARTICLE; 156-161; 638
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/475658]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang, Meng-Lin,Fu, Feng-Hua,Yu, Long-Chuan. Antinociception induced by galanin in anterior cingulate cortex in rats with acute inflammation[J]. NEUROSCIENCE LETTERS,2017.
APA	Zhang, Meng-Lin,Fu, Feng-Hua,&Yu, Long-Chuan.(2017).Antinociception induced by galanin in anterior cingulate cortex in rats with acute inflammation.NEUROSCIENCE LETTERS.
MLA	Zhang, Meng-Lin,et al."Antinociception induced by galanin in anterior cingulate cortex in rats with acute inflammation".NEUROSCIENCE LETTERS (2017).

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