Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in   Neurons

doi:10.3389/fnmol.2017.00047

CORC > 北京大学 > 生命科学学院

	Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in Neurons
	Xie, Zhenli ; Long, Jiangang ; Liu, Jiankang ; Chai, Zuying ; Kang, Xinjiang ; Wang, Changhe
刊名	FRONTIERS IN MOLECULAR NEUROSCIENCE
	2017
关键词	exocytosis endocytosis vesicle recycling calmodulin synaptotagmin SNARE SYNAPTIC-VESICLE ENDOCYTOSIS CLATHRIN-MEDIATED ENDOCYTOSIS DEPENDENT BULK ENDOCYTOSIS KISS-AND-RUN ADRENAL CHROMAFFIN CELLS FUSION PORE EXPANSION SYNAPTOTAGMIN-I HIPPOCAMPAL SYNAPSES SLOW ENDOCYTOSIS NERVE-TERMINALS
DOI	10.3389/fnmol.2017.00047
英文摘要	Neuronal communication and brain function mainly depend on the fundamental biological events of neurotransmission, including the exocytosis of presynaptic vesicles (SVs) for neurotransmitter release and the subsequent endocytosis for SV retrieval. Neurotransmitters are released through the Ca2+-and SNARE-dependent fusion of SVs with the presynaptic plasma membrane. Following exocytosis, endocytosis occurs immediately to retrieve SV membrane and fusion machinery for local recycling and thus maintain the homeostasis of synaptic structure and sustained neurotransmission. Apart from the general endocytic machinery, recent studies have also revealed the involvement of SNARE proteins (synaptobrevin, SNAP25 and syntaxin), synaptophysin, Ca2+/ calmodulin, and members of the synaptotagmin protein family (Syt1, Syt4, Syt7 and Syt11) in the balance and tight coupling of exo-endocytosis in neurons. Here, we provide an overview of recent progress in understanding how these neuronspecific adaptors coordinate to ensure precise and efficient endocytosis during neurotransmission.; National Natural Science Foundation of China [31400708, 81571235, 31670843]; Natural Science Foundation of Heilongjiang Province of China [C201453]; Natural Science Foundation of Shandong Province of China [ZR2016CM16]; Scientific Research Fund of Heilongjiang Provincial Education Department [12531750, 12531746]; start-up funding of Liaocheng University [318051525]; SCI(E); REVIEW; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/474613]
专题	生命科学学院
推荐引用方式 GB/T 7714	Xie, Zhenli,Long, Jiangang,Liu, Jiankang,et al. Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in Neurons[J]. FRONTIERS IN MOLECULAR NEUROSCIENCE,2017.
APA	Xie, Zhenli,Long, Jiangang,Liu, Jiankang,Chai, Zuying,Kang, Xinjiang,&Wang, Changhe.(2017).Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in Neurons.FRONTIERS IN MOLECULAR NEUROSCIENCE.
MLA	Xie, Zhenli,et al."Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in Neurons".FRONTIERS IN MOLECULAR NEUROSCIENCE (2017).