Photo-controlled release of fipronil from a coumarin triggered precursor

doi:10.1016/j.bmcl.2017.03.091

CORC > 北京大学 > 生命科学学院

	Photo-controlled release of fipronil from a coumarin triggered precursor
	Gao, Zhenhong ; Yuan, Pengtao ; Wang, Donghui ; Xu, Zhiping ; Li, Zhong ; Shao, Xusheng
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2017
关键词	Photocaged Fipronil Coumarin Insecticide Light PHOTOREMOVABLE PROTECTING GROUPS CAGED COMPOUNDS PHOTORELEASE TECHNOLOGY REACTION-MECHANISMS CELLULAR CHEMISTRY GLUCOSE-FIPRONIL LIGHT ACID FORMULATIONS SYSTEMS
DOI	10.1016/j.bmcl.2017.03.091
英文摘要	Developing efficient controlled release system of insecticide can facilitate the better use of insecticide. We described here a first example of photo-controlled release of an insecticide by linking fipronil with photoresponsive coumarin covalently. The generated coumarin-fipronil (CF) precursor could undergo cleavage to release free fipronil in the presence of blue light (420 nm) or sunlight. Photophysical studies of CF showed that it exhibited strong fluorescence properties. The CF had no obvious activity against mosquito larvae under dark, but it can be activated by light inside the mosquito larvae. The released Fip from CF by blue light irradiation in vitro retained its activity to armyworm (Mythimna separate) with LC50 value of 24.64 mu mol L-1. This photocaged molecule provided an alternative delivery method for fipronil. (C) 2017 Published by Elsevier Ltd.; National Natural Science Foundation of China [21372079, 21472046]; Shanghai Pujiang Program [14PJD012]; SCI(E); ARTICLE; 11; 2528-2535; 27
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/473174]
专题	生命科学学院
推荐引用方式 GB/T 7714	Gao, Zhenhong,Yuan, Pengtao,Wang, Donghui,et al. Photo-controlled release of fipronil from a coumarin triggered precursor[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017.
APA	Gao, Zhenhong,Yuan, Pengtao,Wang, Donghui,Xu, Zhiping,Li, Zhong,&Shao, Xusheng.(2017).Photo-controlled release of fipronil from a coumarin triggered precursor.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.
MLA	Gao, Zhenhong,et al."Photo-controlled release of fipronil from a coumarin triggered precursor".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017).