Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated   antiviral immune responses

doi:10.7554/eLife.24425

CORC > 北京大学 > 生命科学学院

	Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses
	Liu, Wei ; Li, Jing ; Zheng, Weinan ; Shang, Yingli ; Zhao, Zhendong ; Wang, Shanshan ; Bi, Yuhai ; Zhang, Shuang ; Xu, Chongfeng ; Duan, Ziyuan ; Zhang, Lianfeng ; Wang, Yue L. ; Jiang, Zhengfan ; Liu, Wenjun ; Sun, Lei
刊名	ELIFE
	2017
关键词	HEPATITIS-C VIRUS NF-KAPPA-B INNATE IMMUNITY SIGNALING ADAPTER MAVS DEGRADATION STRUCTURAL BASIS CYCLOSPORINE-A RNA VIRUSES PROTEIN LIGASE
DOI	10.7554/eLife.24425
英文摘要	RIG-I is a key cytosolic pattern recognition receptor that interacts with MAVS to induce type I interferons (IFNs) against RNA virus infection. In this study, we found that cyclophilin A (CypA), a peptidyl-prolyl cis/trans isomerase, functioned as a critical positive regulator of RIG-I mediated antiviral immune responses. Deficiency of CypA impaired RIG-I-mediated type I IFN production and promoted viral replication in human cells and mice. Upon Sendai virus infection, CypA increased the interaction between RIG-I and its E3 ubiquitin ligase TRIM25, leading to enhanced TRIM25-mediated K63-linked ubiquitination of RIG-I that facilitated recruitment of RIG-I to MAVS. In addition, CypA and TRIM25 competitively interacted with MAVS, thereby inhibiting TRIM25-induced K48-linked ubiquitination of MAVS. Taken together, our findings reveal an essential role of CypA in boosting RIG-I-mediated antiviral immune responses by controlling the ubiquitination of RIG-I and MAVS.; National Natural Science Foundation of China [31472178, 31672531, 31630079, 81621091]; Key Research Program of Chinese Academy of Sciences [KSZD-EW-Z-005-001]; National Key Technology Support Program of China [2015BAD11B02]; SCI(E); ARTICLE; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/472850]
专题	生命科学学院
推荐引用方式 GB/T 7714	Liu, Wei,Li, Jing,Zheng, Weinan,et al. Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses[J]. ELIFE,2017.
APA	Liu, Wei.,Li, Jing.,Zheng, Weinan.,Shang, Yingli.,Zhao, Zhendong.,...&Sun, Lei.(2017).Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses.ELIFE.
MLA	Liu, Wei,et al."Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses".ELIFE (2017).