A potent human neutralizing antibody Fc-dependently reduces established   HBV infections

doi:10.7554/eLife.26738

CORC > 北京大学 > 生命科学学院

	A potent human neutralizing antibody Fc-dependently reduces established HBV infections
	Li, Dan ; He, Wenhui ; Liu, Ximing ; Zheng, Sanduo ; Qi, Yonghe ; Li, Huiyu ; Mao, Fengfeng ; Liu, Juan ; Sun, Yinyan ; Pan, Lijing ; Du, Kaixin ; Ye, Keqiong ; Li, Wenhui ; Sui, Jianhua
刊名	ELIFE
	2017
关键词	HEPATITIS-B-VIRUS TAUROCHOLATE COTRANSPORTING POLYPEPTIDE GAMMA-R INTERACTIONS IN-VIVO MONOCLONAL-ANTIBODY HEPATOCELLULAR-CARCINOMA HIV-1-INFECTED CELLS CD20 IMMUNOTHERAPY HUMAN HEPATOCYTES EFFECTOR-CELLS
DOI	10.7554/eLife.26738
英文摘要	Hepatitis B virus (HBV) infection is a major global health problem. Currently-available therapies are ineffective in curing chronic HBV infection. HBV and its satellite hepatitis D virus (HDV) infect hepatocytes via binding of the preS1 domain of its large envelope protein to sodium taurocholate cotransporting polypeptide (NTCP). Here, we developed novel human monoclonal antibodies that block the engagement of preS1 with NTCP and neutralize HBV and HDV with high potency. One antibody, 2H5-A14, functions at picomolar level and exhibited neutralization-activity-mediated prophylactic effects. It also acts therapeutically by eliciting antibody-Fc-dependent immunological effector functions that impose durable suppression of viral infection in HBV-infected mice, resulting in reductions in the levels of the small envelope antigen and viral DNA, with no emergence of escape mutants. Our results illustrate a novel antibody-Fc-dependent approach for HBV treatment and suggest 2H5-A14 as a novel clinical candidate for HBV prevention and treatment of chronic HBV infection.; Ministry of Science and Technology of the People's Republic of China [2012CB837600, 2014CB849600]; Beijing Council of Science and Technology; National Natural Science Foundation of China [NSFC81525018]; National Science and Technology Project [2013ZX09509102]; SCI(E); ARTICLE; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/470752]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, Dan,He, Wenhui,Liu, Ximing,et al. A potent human neutralizing antibody Fc-dependently reduces established HBV infections[J]. ELIFE,2017.
APA	Li, Dan.,He, Wenhui.,Liu, Ximing.,Zheng, Sanduo.,Qi, Yonghe.,...&Sui, Jianhua.(2017).A potent human neutralizing antibody Fc-dependently reduces established HBV infections.ELIFE.
MLA	Li, Dan,et al."A potent human neutralizing antibody Fc-dependently reduces established HBV infections".ELIFE (2017).