Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects

CORC > 北京大学 > 生命科学学院

	Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects
	Zhao Dongxin ; Chen Song ; Duo Shuguang ; Xiang Chengang ; Jia Jun ; Guo Mina ; Lai Wei ; Lu Shichun ; Deng Hongkui
刊名	Cell Research
	2013
英文摘要	Promoting the functional maturation of the desired cell types derived from human pluripotent stem cells (hPSCs) remains a major challenge, especially for hepatocytes, as routine access to metabolically functional hepatocytes would enable their use in drug toxicity screening. Although previous attempts to induce hepatic specification from hPSCs yielded cells possessing some hepatic features [1-3], most of these cells showed poor metabolic activities, and the responsible mechanisms are unknown. In this study, we explored the intrinsic defects in hPSCderived immature hepatocytes and tested whether correcting these defects would promote the metabolic maturation of the differentiated cells.; The National Basic Research Program of China m(973 program),Bill & Melinda Gates Foundation Grant,The Ministry of Education of China (111 project),Beijing Science and Technology Plan,National Science and Technology Major Project; 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 1; 157-161; 23
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/462139]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhao Dongxin,Chen Song,Duo Shuguang,et al. Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects[J]. Cell Research,2013.
APA	Zhao Dongxin.,Chen Song.,Duo Shuguang.,Xiang Chengang.,Jia Jun.,...&Deng Hongkui.(2013).Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects.Cell Research.
MLA	Zhao Dongxin,et al."Promotion of the efficient metabolic maturation of human pluripotent stem cell-derived hepatocytes by correcting specification defects".Cell Research (2013).