On the Eve of Upgrading Antidepressants: (R)-Ketamine and Its   Metabolites

doi:10.1007/s12264-016-0082-1

CORC > 北京大学 > 生命科学学院

	On the Eve of Upgrading Antidepressants: (R)-Ketamine and Its Metabolites
	Yuan, Kai ; Han, Ying ; Hashimoto, Kenji ; Lu, Lin
刊名	NEUROSCIENCE BULLETIN
	2016
关键词	Upgrading Antidepressants (R)-Ketamine RAPID-ACTING ANTIDEPRESSANTS SUSTAINED ANTIDEPRESSANT R-KETAMINE NMDA ANTAGONISTS MAJOR DEPRESSION MECHANISMS ONSET PLASTICITY RECEPTORS TRIAL
DOI	10.1007/s12264-016-0082-1
英文摘要	Ketamine is a noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist that has attracted widespread attention for its rapid-onset antidepressant effects, especially in individuals with treatment-resistant depression and suicidal ideation. Compared with the traditional antidepressants that take weeks, if not months, to benefit patients and are associated with a high rate of relapse, ketamine exerts its antidepressant effects within several hours. These clinical benefits can last for 2 weeks after a single injection. However, ketamine still has limited clinical application, mainly because of its psychotomimetic side-effects and liability of abuse. A recent paper in Nature showed that the ketamine metabolite enantiomer (2R,6R)-hydroxynorketamine (HNK) has rapid and sustained antidepressant effects without the side-effects associated with ketamine, such as abuse potential. The discovery of (R)-ketamine is a landmark in the field of depression. Investigations of its mechanism of action will inspire the development of a new generation of rapid-acting antidepressants that are safer and have few dissociative side-effects.; SCI(E); 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); EDITORIAL MATERIAL; linlu@bjmu.edu.cn; 6; 565-568; 32
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/458282]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Yuan, Kai,Han, Ying,Hashimoto, Kenji,et al. On the Eve of Upgrading Antidepressants: (R)-Ketamine and Its Metabolites[J]. NEUROSCIENCE BULLETIN,2016.
APA	Yuan, Kai,Han, Ying,Hashimoto, Kenji,&Lu, Lin.(2016).On the Eve of Upgrading Antidepressants: (R)-Ketamine and Its Metabolites.NEUROSCIENCE BULLETIN.
MLA	Yuan, Kai,et al."On the Eve of Upgrading Antidepressants: (R)-Ketamine and Its Metabolites".NEUROSCIENCE BULLETIN (2016).