Oscillatory stress stimulation uncovers an Achilles&apos; heel of the yeast   MAPK signaling network

doi:10.1126/science.aab0892

CORC > 北京大学 > 生命科学学院

	Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network
	Mitchell, Amir ; Wei, Ping ; Lim, Wendell A.
刊名	SCIENCE
	2015
关键词	CELLULAR INFORMATION SCAFFOLD KINASE PATHWAYS HOG SPECIFICITY ACTIVATION PROTEINS DYNAMICS
DOI	10.1126/science.aab0892
英文摘要	Cells must interpret environmental information that often changes over time. In our experiment, we systematically monitored the growth of yeast cells under various frequencies of oscillating osmotic stress. Growth was severely inhibited at a particular resonance frequency, at which cells show hyperactivated transcriptional stress responses. This behavior represents a sensory misperception: The cells incorrectly interpret oscillations as a staircase of ever-increasing osmolarity. The misperception results from the capacity of the osmolarity-sensing mitogen-activated protein kinase (MAPK) network to retrigger with sequential osmotic stresses. Although this feature is critical for coping with natural challenges, such as continually increasing osmolarity, it results in a trade-off of fragility to non-natural oscillatory inputs that match the retriggering time. These findings demonstrate the value of non-natural dynamic perturbations in exposing hidden sensitivities of cellular regulatory networks.; NIH [R01 GM55040, R01 GM62583, PN2 EY016546, P50 GM081879]; NSF Synthetic Biology Engineering Research Center (SynBERC); HHMI; MOST [2015CB910300]; National Natural Science Foundation of China [31470819]; Peking-Tsinghua Center for Life Sciences; Program for Breakthrough Biomedical Research Postdoctoral Research Award (UCSF); SCI(E); ARTICLE; pwei@pku.edu.cn; lim@cmp.ucsf.edu; 6266; 1379-1383; 350
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/439071]
专题	生命科学学院
推荐引用方式 GB/T 7714	Mitchell, Amir,Wei, Ping,Lim, Wendell A.. Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network[J]. SCIENCE,2015.
APA	Mitchell, Amir,Wei, Ping,&Lim, Wendell A..(2015).Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network.SCIENCE.
MLA	Mitchell, Amir,et al."Oscillatory stress stimulation uncovers an Achilles' heel of the yeast MAPK signaling network".SCIENCE (2015).