Altered expression of mRNA profiles in blood of early-onset   schizophrenia

doi:10.1038/srep16767

CORC > 北京大学 > 生命科学学院

	Altered expression of mRNA profiles in blood of early-onset schizophrenia
	Xu, Yong ; Shugart, Yin Yao ; Wang, Guoqiang ; Cheng, Zaohuo ; Jin, Chunhui ; Zhang, Kai ; Wang, Jun ; Yu, Hao ; Yue, Weihua ; Zhang, Fuquan ; Zhang, Dai
刊名	SCIENTIFIC REPORTS
	2016
关键词	GENE COEXPRESSION NETWORKS SIGNALING PATHWAYS MUTANT MICE CTLA4 GENE POLYMORPHISM BRAIN MICROARRAY PROTEIN ABNORMALITIES ASSOCIATION
DOI	10.1038/srep16767
英文摘要	To identify gene expression abnormalities in schizophrenia (SZ), we generated whole-genome gene expression profiles using microarrays on peripheral blood mononuclear cells (PBMCs) from 18 early-onset SZ cases and 12 controls. We detected 84 transcripts differentially expressed by diagnostic status, with 82 genes being upregulated and 2 downregulated. We identified two SZ associated gene coexpression modules (green and red), including 446 genes. The green module is positively correlated with SZ, encompassing predominantly up-regulated genes in SZ; while the red module was negatively correlated with disease status, involving mostly nominally down-regulated genes in SZ. The olfactory transduction pathway was the most enriched pathways for the genes within the two modules. The expression levels of several hub genes, including AKT1, BRCA1, CCDC134, UBD, and ZIC2 were validated using real-time quantitative PCR. Our findings indicate that mRNA coexpression abnormalities may serve as a promising mechanism underlying the development of SZ.; National Natural Science Foundation of China [81471364, 81271482, 81571319]; Beijing Natural Science Foundation [7132182]; Program for New Century Excellent Talents in University [NCET-12-1036]; Intramural Research Program of National Institute of Mental Health, National Institutes of Health [MH002929-05]; SCI(E); PubMed; ARTICLE; dryue@bjmu.edu.cn; zhangfq@njmu.edu.cn; 16767; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435489]
专题	生命科学学院
推荐引用方式 GB/T 7714	Xu, Yong,Shugart, Yin Yao,Wang, Guoqiang,et al. Altered expression of mRNA profiles in blood of early-onset schizophrenia[J]. SCIENTIFIC REPORTS,2016.
APA	Xu, Yong.,Shugart, Yin Yao.,Wang, Guoqiang.,Cheng, Zaohuo.,Jin, Chunhui.,...&Zhang, Dai.(2016).Altered expression of mRNA profiles in blood of early-onset schizophrenia.SCIENTIFIC REPORTS.
MLA	Xu, Yong,et al."Altered expression of mRNA profiles in blood of early-onset schizophrenia".SCIENTIFIC REPORTS (2016).