Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells | |
Xia, Weiwei ; Zhang, Aihua ; Jia, Zhanjun ; Gu, Jun ; Chen, Hongbing | |
刊名 | MEDIATORS OF INFLAMMATION
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2016 | |
关键词 | CORONARY-HEART-DISEASE CARDIOVASCULAR-DISEASE INFLAMMATION INTERLEUKIN-6 ATHEROSCLEROSIS EXPRESSION PATHWAY RISK GENE MICE |
DOI | 10.1155/2016/2193210 |
英文摘要 | Both statins and klotho have been shown to be beneficial in vascular diseases. Interleukin- (IL-) 6 is evidenced as an indicator reflecting the stability of atherosclerotic plaque and involved in the pathogenesis of artery atherosclerosis. However, the relationship between statin, klotho, and IL-6 under an inflammatory environment is unknown. Using primary human umbilical vein endothelial cells (HUVECs), pravastatin dose-dependently induced klotho expression in contrast to remarkable suppression to IL-6 expressions determined by qRT-PCR. Moreover, TNF-alpha-induced IL-6 was partly but significantly blunted by pravastatin detected by ELISA. To further study the role of klotho in modulating IL-6 expression, endothelial cells with klotho overexpression were treated with TNF-alpha. Importantly, TNF-alpha-induced IL-6 production was markedly attenuated in klotho-overexpressed cells. In agreement with in vitro data, a marked reduction of klotho mRNA expression was found in isolated peripheral blood mononuclear cells (PBMCs) from patients with atherosclerosis. Together, these data suggested that pravastatin could suppress IL-6 production via promoting klotho expression in endothelial cells under inflammatory stimuli.; Nanjing Medical University [2015NJMUZD053]; Nanjing Children Hospital [ETYY2013025]; National Natural Science Foundation of China [81370802]; SCI(E); PubMed; ARTICLE; jiazj72@hotmail.com; gj@pku.edu.cn; chenghb1999@126.com; 2193210; 2016 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/434291] ![]() |
专题 | 生命科学学院 |
推荐引用方式 GB/T 7714 | Xia, Weiwei,Zhang, Aihua,Jia, Zhanjun,et al. Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells[J]. MEDIATORS OF INFLAMMATION,2016. |
APA | Xia, Weiwei,Zhang, Aihua,Jia, Zhanjun,Gu, Jun,&Chen, Hongbing.(2016).Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells.MEDIATORS OF INFLAMMATION. |
MLA | Xia, Weiwei,et al."Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells".MEDIATORS OF INFLAMMATION (2016). |
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