The transcriptional repressor Hes1 attenuates inflammation by regulating   transcription elongation

doi:10.1038/ni.3486

CORC > 北京大学 > 生命科学学院

	The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation
	Shang, Yingli ; Coppo, Maddalena ; He, Teng ; Ning, Fei ; Yu, Li ; Kang, Lan ; Zhang, Bin ; Ju, Chanyang ; Qiao, Yu ; Zhao, Baohong ; Gessler, Manfred ; Rogatsky, Inez ; Hu, Xiaoyu
刊名	NATURE IMMUNOLOGY
	2016
关键词	RNA-POLYMERASE-II NF-KAPPA-B MACROPHAGE POLARIZATION UP-REGULATION NOTCH ACTIVATION CELLS CHEMOKINES DISEASE GENES
DOI	10.1038/ni.3486
英文摘要	Most of the known regulatory mechanisms that curb inflammatory gene expression target pre-transcription-initiation steps, and evidence for post-initiation regulation of inflammatory gene expression remains scarce. We found that the transcriptional repressor Hes1 suppressed production of CXCL1, a chemokine that is crucial for recruiting neutrophils. Hes1 negatively regulated neutrophil recruitment in vivo in a manner that was dependent on macrophage-produced CXCL1, and it attenuated the severity of inflammatory arthritis. Mechanistically, inhibition of Cxcl1 expression by Hes1 did not involve modification of transcription initiation. Instead, Hes1 inhibited signal-induced recruitment of the positive transcription-elongation complex P-TEFb and thereby prevented phosphorylation of RNA polymerase II at Ser2 and productive elongation. Thus, our results identify Hes1 as a homeostatic suppressor of inflammatory responses that exerts its suppressive function by regulating transcription elongation.; Ministry of Science and Technology of China [2015CB943201]; National Natural Science Foundation of China [81422019]; Tsinghua-Peking Center for Life Sciences; Institute for Immunology at Tsinghua University; David Rosensweig HSS Genomics Center; Rheumatology Research Foundation; US Department of Defense; US National Institutes of Health; SCI(E); PubMed; ARTICLE; xiaoyuhu@tsinghua.edu.cn; 8; 930-+; 17
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/433259]
专题	生命科学学院
推荐引用方式 GB/T 7714	Shang, Yingli,Coppo, Maddalena,He, Teng,et al. The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation[J]. NATURE IMMUNOLOGY,2016.
APA	Shang, Yingli.,Coppo, Maddalena.,He, Teng.,Ning, Fei.,Yu, Li.,...&Hu, Xiaoyu.(2016).The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation.NATURE IMMUNOLOGY.
MLA	Shang, Yingli,et al."The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation".NATURE IMMUNOLOGY (2016).