An Atlas of Network Topologies Reveals Design Principles for   Caenorhabditis elegans Vulval Precursor Cell Fate Patterning

doi:10.1371/journal.pone.0131397

CORC > 北京大学 > 生命科学学院

	An Atlas of Network Topologies Reveals Design Principles for Caenorhabditis elegans Vulval Precursor Cell Fate Patterning
	Ping, Xianfeng ; Tang, Chao
刊名	PLOS ONE
	2015
关键词	C-ELEGANS SIGNALING NETWORK ROBUSTNESS INDUCTION LIN-12/NOTCH CROSSTALK EPISTASIS PATHWAYS NEMATODE MOTIFS
DOI	10.1371/journal.pone.0131397
英文摘要	The vulval precursor cell (VPC) fate patterning in Caenorhabditis elegans is a classic model experimental system for cell fate determination and patterning in development. Despite its apparent simplicity (six neighboring cells arranged in one dimension) and many experimental and computational efforts, the patterning strategy and mechanism remain controversial due to incomplete knowledge of the complex biology. Here, we carry out a comprehensive computational analysis and obtain a reservoir of all possible network topologies that are capable of VPC fate patterning under the simulation of various biological environments and regulatory rules. We identify three patterning strategies: sequential induction, morphogen gradient and lateral antagonism, depending on the features of the signal secreted from the anchor cell. The strategy of lateral antagonism, which has not been reported in previous studies of VPC patterning, employs a mutual inhibition of the 2 degrees cell fate in neighboring cells. Robust topologies are built upon minimal topologies with basic patterning strategies and have more flexible and redundant implementations of modular functions. By simulated mutation, we find that all three strategies can reproduce experimental error patterns of mutants. We show that the topology derived by mapping currently known biochemical pathways to our model matches one of our identified functional topologies. Furthermore, our robustness analysis predicts a possible missing link related to the lateral antagonism strategy. Overall, we provide a theoretical atlas of all possible functional networks in varying environments, which may guide novel discoveries of the biological interactions in vulval development of Caenorhabditis elegans and related species.; National Natural Science Foundation of China [91430217]; Ministry of Science and Technology of the People's Republic of China (CN) [2015CB910300]; China Scholarship Council; SCI(E); PubMed; ARTICLE; tangc@pku.edu.cn; 6; e0131397; 10
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/419090]
专题	生命科学学院
推荐引用方式 GB/T 7714	Ping, Xianfeng,Tang, Chao. An Atlas of Network Topologies Reveals Design Principles for Caenorhabditis elegans Vulval Precursor Cell Fate Patterning[J]. PLOS ONE,2015.
APA	Ping, Xianfeng,&Tang, Chao.(2015).An Atlas of Network Topologies Reveals Design Principles for Caenorhabditis elegans Vulval Precursor Cell Fate Patterning.PLOS ONE.
MLA	Ping, Xianfeng,et al."An Atlas of Network Topologies Reveals Design Principles for Caenorhabditis elegans Vulval Precursor Cell Fate Patterning".PLOS ONE (2015).