Involvement of galanin receptor 2 and CaMKII in galanin-induced   antinociception in periaqueductal grey of rats

doi:10.1016/j.neulet.2015.08.005

CORC > 北京大学 > 生命科学学院

	Involvement of galanin receptor 2 and CaMKII in galanin-induced antinociception in periaqueductal grey of rats
	Zhang, Xi-Yue ; Zhang, Yi-Ming ; Zhang, Meng-Lin ; Yu, Long-Chuan
刊名	NEUROSCIENCE LETTERS
	2015
关键词	Antinociceptive effect Ca(2+)/calmodulin-dependent kinase II (CaMKII) Galanin Galanin receptor 2 Hindpaw withdrawal latency Periaqueductal grey (PAG) PAIN-RELATED BEHAVIOR PROTEIN-KINASE-II NEURONS MONONEUROPATHY INJECTION NUCLEUS
DOI	10.1016/j.neulet.2015.08.005
英文摘要	The present study was performed to explore the effect of the galanin receptor 2 (GalR2) antagonist M871 on the galanin-induced antinociception in periaqueductal grey (PAG), and an involvement of Ca(2+)/calmodulin-dependent kinase II (CaMKII) in the galanin-induced antinociception. Intra-PAG injection of galanin induced marked increases in HWLs to noxious thermal and mechanical stimulation. The increased HWLs to thermal and mechanical stimulation decreased significantly after intra-PAG administration of the GalR2 antagonist M871, indicating an involvement of GalR2 in the galanin-induced antinociception in PAG of rats. Furthermore, rats received intra-PAG injection of galanin, followed 5 min later by intra-PAG administration of the CaMKII inhibitor MAP. The galanin-induced increases in HWLs to thermal and mechanical stimulation decreased significantly after intra-PAG administration of MAP, indicating that there is an involvement of CaMKII in the galanin-induced antinociception in PAG, blockade the activity of CaMKII by MAP inhibits the galanin-induced antinociception in PAG of rats. Our results strongly indicate that the galanin-induced antinociception is mediated by GalR2 in the PAG, and CaMKII may be involved in the galanin-induced antinociception in PAG of rats. (C) 2015 Elsevier Ireland Ltd. All rights reserved.; XIETONG Foundation of Yantai University; National Natural Science Foundation of China (NSFC) [30870802, 81171043]; SCI(E); PubMed; ARTICLE; yulc@pku.edu.cn; 124-127; 604
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/416293]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang, Xi-Yue,Zhang, Yi-Ming,Zhang, Meng-Lin,et al. Involvement of galanin receptor 2 and CaMKII in galanin-induced antinociception in periaqueductal grey of rats[J]. NEUROSCIENCE LETTERS,2015.
APA	Zhang, Xi-Yue,Zhang, Yi-Ming,Zhang, Meng-Lin,&Yu, Long-Chuan.(2015).Involvement of galanin receptor 2 and CaMKII in galanin-induced antinociception in periaqueductal grey of rats.NEUROSCIENCE LETTERS.
MLA	Zhang, Xi-Yue,et al."Involvement of galanin receptor 2 and CaMKII in galanin-induced antinociception in periaqueductal grey of rats".NEUROSCIENCE LETTERS (2015).