Netrin signal transduction and the guanine nucleotide exchange factor   DOCK180 in attractive signaling

doi:10.1038/nn2022

CORC > 北京大学 > 生命科学学院

	Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling
	Li, Xiaoling ; Gao, Xue ; Liu, Guofa ; Xiong, Wencheng ; Wu, Jane ; Rao, Yi
刊名	自然神经科学
	2008
关键词	COMMISSURAL AXON GUIDANCE FOCAL ADHESION KINASE C-ELEGANS COLORECTAL-CANCER CELL-MIGRATION CAENORHABDITIS-ELEGANS GENETIC-ANALYSIS NERVOUS-SYSTEM MYOBLAST CITY GUIDES CELL
DOI	10.1038/nn2022
英文摘要	Netrins are prototypical axon guidance cues whose attractive signaling requires the small GTPase Rac1. It remains unclear how Rac1 is regulated in the netrin pathway. DOCK180 is a member of a new family of guanine nucleotide exchange factors for Rho GTPases. Here we provide evidence implicating DOCK180 in netrin signal transduction. Netrin promoted the formation of a protein-protein interaction complex that included DOCK180 and the netrin receptor deleted in colorectal carcinoma (DCC). Inhibition of DOCK180 reduced activation of Rac1 by netrin. Both axon outgrowth and axon attraction induced by netrin were inhibited after DOCK180 knockdown in vertebrate neurons. The in vivo functional role of DOCK180 was demonstrated by its requirement for projection of commissural axons in the neural tube. These findings indicate that netrin stimulation recruits DOCK180 through DCC, which then activates small GTPases, suggesting an essential role for DOCK180 in mediating attractive responses by neurons to netrin-1.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000252117900009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); 53; ARTICLE; 1; 28-35; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/401375]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, Xiaoling,Gao, Xue,Liu, Guofa,et al. Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling[J]. 自然神经科学,2008.
APA	Li, Xiaoling,Gao, Xue,Liu, Guofa,Xiong, Wencheng,Wu, Jane,&Rao, Yi.(2008).Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling.自然神经科学.
MLA	Li, Xiaoling,et al."Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling".自然神经科学 (2008).