TNFR-associated factor-3 is associated with BAFF-R and negatively   regulates BAFF-R-mediated NF-kappa B activation and IL-10 production

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	TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production
	Xu, LG ; Shu, HB
刊名	journal of immunology
	2002
关键词	NECROSIS-FACTOR FAMILY LYMPHOTOXIN-BETA RECEPTOR CELL MATURATION AUTOIMMUNE-DISEASE TERMINAL KINASE FACTORS TRAFS MEMBER CD40 TACI PROTEIN
英文摘要	TALL-1 is a member of the TNF family that is critically involved in B cell survival, maturation, and progression of lupus-like autoimmune diseases. TALL-1 has three receptors, including BCMA, TACI, and BAFF-R, which are mostly expressed by B lymphocytes. Gene knockout studies have indicated that BAFF-R is the major stimulatory receptor for TALL-1 signaling and is required for normal B cell development. The intracellular signaling mechanisms of BAFF-R are not known. In this report, we attempted to identify BAFF-R-associated downstream proteins by yeast two-hybrid screening. This effort identified TNFR-associated factor (TRAF)3 as a protein specifically interacting with BAFF-R in yeast two-hybrid assays. Coimmunoprecipitation experiments indicated that BAFF-R interacts with TRAF3 in B lymphoma cells and this interaction is stimulated by TALL-1 treatment. Domain mapping experiments indicated that both a 6-aa membrane proximal region and the C-terminal 35 aa of BAFF-R are required for its interaction with TRAF3. Moreover, overexpression of TRAF3 inhibits BAFF-R-mediated NF-kappaB activation and IL-10 production. Taken together, our findings suggest that TRAF3 is a negative regulator of BAFF-R-mediated NF-kappaB activation and IL-10 production.; Immunology; SCI(E); 92; ARTICLE; 12; 6883-6889; 169
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/401007]
专题	生命科学学院
推荐引用方式 GB/T 7714	Xu, LG,Shu, HB. TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production[J]. journal of immunology,2002.
APA	Xu, LG,&Shu, HB.(2002).TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production.journal of immunology.
MLA	Xu, LG,et al."TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production".journal of immunology (2002).