Anti-nociceptive role of neuropeptide Y in the nucleus accumbens in rats   with inflammation, an effect modulated by mu- and kappa-opioid receptors

doi:10.1080/10020070612331343204

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	Anti-nociceptive role of neuropeptide Y in the nucleus accumbens in rats with inflammation, an effect modulated by mu- and kappa-opioid receptors
	Li, JJ ; Yu, LC
刊名	progress in natural science
	2006
关键词	nucleus accumbens neuropeptide Y Y1 receptor carrageenan anti-nociception mu and kappa-opioid receptors GENE-RELATED PEPTIDE PERIAQUEDUCTAL GREY DESCENDING PATHWAY SPINAL-CORD INVOLVEMENT ANALGESIA MORPHINE MICE RESPONSES NALOXONE
DOI	10.1080/10020070612331343204
英文摘要	Recent study in our laboratory showed that neuropeptide Y (NPY) plays an antinociceptive role in the nucleus accumbens (NAc) in intact rats. The present study was performed to further investigate the effect of NPY in nociceptive modulation in the NAc of rats with inflammation, and the possible interaction between NPY and the opioid systems. Experimental inflammation was induced by subcutaneous injection of carrageenan into the left hindpaw of rats. Infra-NAc administration of NPY induced a dose-dependent increase of hindpaw withdrawal latencies (HWLs) to thermal and mechanical stimulations in rats with inflammation. The anti-nociceptive effect of NPY was significantly blocked by subsequent intra-NAc injection of the Y1 receptor antagonist NPY28-36, suggesting an involvement of Y1 receptor in the NPY-induced anti-nociception. Furthermore, infra-NAc administration of the opioid antagonist naloxone significantly antagonized the increased HWLs induced by preceding infra-NAc injection of NPY, suggesting an involvement of the endogenous opioid system in the NPY-induced anti-nociception in the NAc during inflammation. Moreover, the NPY-induced anti-nociception was attenuated by following intra-NAc injection of the mu-opioid antagonist beta-funaltrexamine (beta-FNA), and kappa-opioid antagonist nor-binaltorphimine (nor-BNI), but not by delta-opioid antagonist naltrindole, indicating that mu- and kappa-opioid receptors, not a-opioid receptor, are involved in the NPY-induced anti-nociception in the NAc in rats with inflammation.; Materials Science, Multidisciplinary; Multidisciplinary Sciences; SCI(E); 0; ARTICLE; 2; 133-141; 16
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/398796]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, JJ,Yu, LC. Anti-nociceptive role of neuropeptide Y in the nucleus accumbens in rats with inflammation, an effect modulated by mu- and kappa-opioid receptors[J]. progress in natural science,2006.
APA	Li, JJ,&Yu, LC.(2006).Anti-nociceptive role of neuropeptide Y in the nucleus accumbens in rats with inflammation, an effect modulated by mu- and kappa-opioid receptors.progress in natural science.
MLA	Li, JJ,et al."Anti-nociceptive role of neuropeptide Y in the nucleus accumbens in rats with inflammation, an effect modulated by mu- and kappa-opioid receptors".progress in natural science (2006).