Comparison of vesicular stomatitis virus pseudotyped with the S proteins   from a porcine and a human coronavirus

doi:10.1099/vir.0.009704-0

CORC > 北京大学 > 生命科学学院

	Comparison of vesicular stomatitis virus pseudotyped with the S proteins from a porcine and a human coronavirus
	Schwegmann-Wessels, Christel ; Glende, Joerg ; Ren, Xiaofeng ; Qu, Xiuxia ; Deng, Hongkui ; Enjuanes, Luis ; Herrler, Georg
刊名	journal of general virology
	2009
关键词	TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS RESPIRATORY SYNDROME CORONAVIRUS SARS-CORONAVIRUS FUNCTIONAL RECEPTOR ENVELOPE PROTEINS SPIKE PROTEIN CELL-SURFACE VIRAL ENTRY GLYCOPROTEIN BINDING
DOI	10.1099/vir.0.009704-0
英文摘要	The surface proteins S of severe acute respiratory syndrome coronavirus (SARS-CoV) and transmissible gastroenteritis virus (TGEV) were compared for their ability to mediate infection of viral pseudotypes based on vesicular stomatitis virus (VSV). The cell tropism of the respective pseudotypes corresponded to the tropism of the viruses from which the S protein was derived. Higher infectivity values were obtained with the SARS-CoV S protein than with the TGEV S protein. Differences were observed with respect to the importance of the cytoplasmic tail and the membrane anchor of the S proteins. In the case of the SARS-CoV S protein, truncation of the cytoplasmic tail resulted in increased infectivity. For the TGEV S protein, the inactivation of an intracellular retention signal in the cytoplasmic tail was required. Exchange of the membrane anchor of the S proteins led to a low infection efficiency. Our results indicate that related glycoproteins may show substantial differences in their ability to mediate pseudotype infection.; Biotechnology & Applied Microbiology; Virology; SCI(E); 10; ARTICLE; 1724-1729; 90
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/396927]
专题	生命科学学院
推荐引用方式 GB/T 7714	Schwegmann-Wessels, Christel,Glende, Joerg,Ren, Xiaofeng,et al. Comparison of vesicular stomatitis virus pseudotyped with the S proteins from a porcine and a human coronavirus[J]. journal of general virology,2009.
APA	Schwegmann-Wessels, Christel.,Glende, Joerg.,Ren, Xiaofeng.,Qu, Xiuxia.,Deng, Hongkui.,...&Herrler, Georg.(2009).Comparison of vesicular stomatitis virus pseudotyped with the S proteins from a porcine and a human coronavirus.journal of general virology.
MLA	Schwegmann-Wessels, Christel,et al."Comparison of vesicular stomatitis virus pseudotyped with the S proteins from a porcine and a human coronavirus".journal of general virology (2009).