First Report of Putative Streptococcus pneumoniae Serotype 6D among   Nasopharyngeal Isolates from Fijian Children

doi:10.1086/606118

CORC > 北京大学 > 生命科学学院

	First Report of Putative Streptococcus pneumoniae Serotype 6D among Nasopharyngeal Isolates from Fijian Children
	Jin, Ping ; Kong, Fanrong ; Xiao, Meng ; Oftadeh, Shahin ; Zhou, Fei ; Liu, Chunyi ; Russell, Fiona ; Gilbert, Gwendolyn L.
刊名	journal of infectious diseases
	2009
关键词	BLOT HYBRIDIZATION ASSAY PNEUMOCOCCAL SEROTYPE CONJUGATE VACCINE 6C PCR SEROGROUP-6 PREVALENCE DISEASE 6A
DOI	10.1086/606118
英文摘要	Background. A putative Streptococcus pneumoniae serotype, 6D, resulting from the introduction of wciN(beta) into serotype 6B has been proposed. Methods. We studied 98 unique serogroup 6 isolates from Fijian children, two-thirds of whom had received at least 1 dose of 7-valent pneumococcal conjugate vaccine, and 51 invasive isolates from Australian children. We used a polymerase chain reaction (PCR) system that targets both wciN(beta) and the single-nucleotide polymorphism that differentiates serotypes 6A and 6B-wciP584g (6A) and wciP584a (6B). Results. Two (9%) of 22 Australian isolates and 24 (38%) of 64 Fijian isolates previously identified as 6A by the Quellung reaction and wciP584g PCR contained wciN(beta) and were designated as 6C; 14 (41%) of 34 Fijian isolates previously identified as 6B by the Quellung reaction and wciP584a PCR contained wciN(beta) and were designated as the new putative serotype 6D. A significantly smaller proportion of children from whom serotype 6D was isolated (2/14 [14%]) had not received PCV-7, compared with the proportion of those from whom serotype 6B was isolated (11/20 [55%]) (P < .05). Conclusion. This is the first report of naturally occurring S. pneumoniae serotype 6D.; Immunology; Infectious Diseases; Microbiology; SCI(E); 84; ARTICLE; 9; 1375-1380; 200
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/396223]
专题	生命科学学院
推荐引用方式 GB/T 7714	Jin, Ping,Kong, Fanrong,Xiao, Meng,et al. First Report of Putative Streptococcus pneumoniae Serotype 6D among Nasopharyngeal Isolates from Fijian Children[J]. journal of infectious diseases,2009.
APA	Jin, Ping.,Kong, Fanrong.,Xiao, Meng.,Oftadeh, Shahin.,Zhou, Fei.,...&Gilbert, Gwendolyn L..(2009).First Report of Putative Streptococcus pneumoniae Serotype 6D among Nasopharyngeal Isolates from Fijian Children.journal of infectious diseases.
MLA	Jin, Ping,et al."First Report of Putative Streptococcus pneumoniae Serotype 6D among Nasopharyngeal Isolates from Fijian Children".journal of infectious diseases (2009).