Structure of transcription factor HetR required for heterocyst   differentiation in cyanobacteria

doi:10.1073/pnas.1106840108

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	Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria
	Kim, Youngchang ; Joachimiak, Grazyna ; Ye, Zi ; Binkowski, T. Andrew ; Zhang, Rongguang ; Gornicki, Piotr ; Callahan, Sean M. ; Hess, Wolfgang R. ; Haselkorn, Robert ; Joachimiak, Andrzej
刊名	proceedings of the national academy of sciences of the united states of america
	2011
关键词	Anabaena/Fischerella HTH motifs palindrome binding patterned development ANABAENA SP PCC-7120 STRAIN PCC 7120 CRYSTAL-STRUCTURE FILAMENTOUS CYANOBACTERIA BINDING SITES DNA-BINDING PROTEIN RESOLUTION EXPRESSION REPRESSOR
DOI	10.1073/pnas.1106840108
英文摘要	HetR is an essential regulator of heterocyst development in cyanobacteria. HetR binds to a DNA palindrome upstream of the hetP gene. We report the crystal structure of HetR from Fischerella at 3.0 angstrom. The protein is a dimer comprised of a central DNA-binding unit containing the N-terminal regions of the two subunits organized with two helix-turn-helix motifs; two globular flaps extending in opposite directions; and a hood over the central core formed from the C-terminal subdomains. The flaps and hood have no structural precedent in the protein database, therefore representing new folds. The structural assignments are supported by site-directed mutagenesis and DNA-binding studies. We suggest that HetR serves as a scaffold for assembly of transcription components critical for heterocyst development.; Multidisciplinary Sciences; SCI(E); 18; ARTICLE; 25; 10109-10114; 108
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/394728]
专题	生命科学学院
推荐引用方式 GB/T 7714	Kim, Youngchang,Joachimiak, Grazyna,Ye, Zi,et al. Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria[J]. proceedings of the national academy of sciences of the united states of america,2011.
APA	Kim, Youngchang.,Joachimiak, Grazyna.,Ye, Zi.,Binkowski, T. Andrew.,Zhang, Rongguang.,...&Joachimiak, Andrzej.(2011).Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria.proceedings of the national academy of sciences of the united states of america.
MLA	Kim, Youngchang,et al."Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria".proceedings of the national academy of sciences of the united states of america (2011).