Guanylate Binding Protein 4 Negatively Regulates Virus-Induced Type I   IFN and Antiviral Response by Targeting IFN Regulatory Factor 7

doi:10.4049/jimmunol.1003691

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	Guanylate Binding Protein 4 Negatively Regulates Virus-Induced Type I IFN and Antiviral Response by Targeting IFN Regulatory Factor 7
	Hu, Yu ; Wang, Jie ; Yang, Bo ; Zheng, Nuoyan ; Qin, Meiling ; Ji, Yongyong ; Lin, Guomei ; Tian, Lin ; Wu, Xiaodong ; Wu, Li ; Sun, Bing
刊名	journal of immunology
	2011
关键词	TOLL-LIKE RECEPTOR NF-KAPPA-B INTERFERON-ALPHA INDUCTION INNATE IMMUNITY RIG-I MEDIATED DEGRADATION PATHOGEN RECOGNITION INDUCIBLE GTPASES DENDRITIC CELLS RNA HELICASE
DOI	10.4049/jimmunol.1003691
英文摘要	IRF7 is known as the master regulator in virus-triggered induction of type I IFNs (IFN-I). In this study, we identify GBP4 virus-induced protein interacting with IRF7 as a negative regulator for IFN-I response. Overexpression of GBP4 inhibits virus-triggered activation of IRF7-dependent signaling, but has no effect on NF-kappa B signaling, whereas the knockdown of GBP4 has opposite effects. Furthermore, the supernatant from Sendai virus-infected cells in which GBP4 have been silenced inhibits the replication of vesicular stomatitis virus more efficiently. Competitive coimmunoprecipitation experiments indicate that overexpression of GBP4 disrupts the interactions between TRAF6 and IRF7, resulting in impaired TRAF6-mediated IRF7 ubiquitination. Our results suggest that GBP4 is a negative regulator of virus-triggered IFN-I production, and it is identified as a novel protein targeting IRF7 and inhibiting its function. The Journal of Immunology, 2011, 187: 6456-6462.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000298167800037&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Immunology; SCI(E); 14; ARTICLE; 12; 6456-6462; 187
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/394039]
专题	生命科学学院
推荐引用方式 GB/T 7714	Hu, Yu,Wang, Jie,Yang, Bo,et al. Guanylate Binding Protein 4 Negatively Regulates Virus-Induced Type I IFN and Antiviral Response by Targeting IFN Regulatory Factor 7[J]. journal of immunology,2011.
APA	Hu, Yu.,Wang, Jie.,Yang, Bo.,Zheng, Nuoyan.,Qin, Meiling.,...&Sun, Bing.(2011).Guanylate Binding Protein 4 Negatively Regulates Virus-Induced Type I IFN and Antiviral Response by Targeting IFN Regulatory Factor 7.journal of immunology.
MLA	Hu, Yu,et al."Guanylate Binding Protein 4 Negatively Regulates Virus-Induced Type I IFN and Antiviral Response by Targeting IFN Regulatory Factor 7".journal of immunology (2011).