Lactation-Related MicroRNA Expression Profiles of Porcine Breast Milk   Exosomes

doi:10.1371/journal.pone.0043691

CORC > 北京大学 > 生命科学学院

	Lactation-Related MicroRNA Expression Profiles of Porcine Breast Milk Exosomes
	Gu, Yiren ; Li, Mingzhou ; Wang, Tao ; Liang, Yan ; Zhong, Zhijun ; Wang, Xiaoyan ; Zhou, Qi ; Chen, Lei ; Lang, Qiulei ; He, Zhiping ; Chen, Xiaohui ; Gong, Jianjun ; Gao, Xiaolian ; Li, Xuewei ; Lv, Xuebin
刊名	plos one
	2012
关键词	IMMUNE-SYSTEM LYMPHOCYTES METASTASIS SIGNATURE EVOLUTION RECEPTOR TARGET CELLS
DOI	10.1371/journal.pone.0043691
英文摘要	Breast milk is the primary source of nutrition for newborns, and is rich in immunological components. MicroRNAs (miRNAs) are present in various body fluids and are selectively packaged inside the exosomes, a type of membrane vesicles, secreted by most cell types. These exosomal miRNAs could be actively delivered into recipient cells, and could regulate target gene expression and recipient cell function. Here, we analyzed the lactation-related miRNA expression profiles in porcine milk exosomes across the entire lactation period (newborn to 28 days after birth) by a deep sequencing. We found that immune-related miRNAs are present and enriched in breast milk exosomes (p<10(-16), chi(2) test) and are generally resistant to relatively harsh conditions. Notably, these exosomal miRNAs are present in higher numbers in the colostrums than in mature milk. It was higher in the serum of colostrum-only fed piglets compared with the mature milk-only fed piglets. These immune-related miRNA-loaded exosomes in breast milk may be transferred into the infant body via the digestive tract. These observations are a prelude to in-depth investigations of the essential roles of breast milk in the development of the infant's immune system.; Multidisciplinary Sciences; SCI(E); 20; ARTICLE; 8; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/392980]
专题	生命科学学院
推荐引用方式 GB/T 7714	Gu, Yiren,Li, Mingzhou,Wang, Tao,et al. Lactation-Related MicroRNA Expression Profiles of Porcine Breast Milk Exosomes[J]. plos one,2012.
APA	Gu, Yiren.,Li, Mingzhou.,Wang, Tao.,Liang, Yan.,Zhong, Zhijun.,...&Lv, Xuebin.(2012).Lactation-Related MicroRNA Expression Profiles of Porcine Breast Milk Exosomes.plos one.
MLA	Gu, Yiren,et al."Lactation-Related MicroRNA Expression Profiles of Porcine Breast Milk Exosomes".plos one (2012).