Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory   type 1 cells

doi:10.1038/nm.3179

CORC > 北京大学 > 生命科学学院

	Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
	Gagliani, Nicola ; Magnani, Chiara F. ; Huber, Samuel ; Gianolini, Monica E. ; Pala, Mauro ; Licona-Limon, Paula ; Guo, Binggege ; Herbert, De&apos ; Bulfone, Alessandro ; Trentini, Filippo ; Di Serio, Clelia ; Bacchetta, Rosa ; Andreani, Marco ; Brockmann, Leonie ; Gregori, Silvia ; Flavell, Richard A. ; Roncarolo, Maria-Grazia ; Broski R.
刊名	自然医学
	2013
关键词	IN-VIVO IMMUNE-RESPONSES CLASS-II T(H)17 CELLS TH17 CELLS INTERLEUKIN-10 EXPRESSION TRANSPLANTATION TOLERANCE DISEASE
DOI	10.1038/nm.3179
英文摘要	CD4(+) type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal role in promoting and maintaining tolerance. The absence of surface markers that uniquely identify Tr1 cells has limited their study and clinical applications. By gene expression profiling of human Tr1 cell clones, we identified the surface markers CD49b and lymphocyte activation gene 3 (LAG-3) as being stably and selectively coexpressed on mouse and human Tr1 cells. We showed the specificity of these markers in mouse models of intestinal inflammation and helminth infection and in the peripheral blood of healthy volunteers. The coexpression of CD49b and LAG-3 enables the isolation of highly suppressive human Tr1 cells from in vitro anergized cultures and allows the tracking of Tr1 cells in the peripheral blood of subjects who developed tolerance after allogeneic hematopoietic stem cell transplantation. The use of these markers makes it feasible to track Tr1 cells in vivo and purify Tr1 cells for cell therapy to induce or restore tolerance in subjects with immune-mediated diseases.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319981600023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental; SCI(E); 170; ARTICLE; 6; 739-+; 19
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/391518]
专题	生命科学学院
推荐引用方式 GB/T 7714	Gagliani, Nicola,Magnani, Chiara F.,Huber, Samuel,et al. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells[J]. 自然医学,2013.
APA	Gagliani, Nicola.,Magnani, Chiara F..,Huber, Samuel.,Gianolini, Monica E..,Pala, Mauro.,...&Broski R..(2013).Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.自然医学.
MLA	Gagliani, Nicola,et al."Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells".自然医学 (2013).