Roles of PINK1, mTORC2, and mitochondria in preserving brain   tumor-forming stem cells in a noncanonical Notch signaling pathway

doi:10.1101/gad.225169.113

CORC > 北京大学 > 生命科学学院

	Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
	Lee, Kyu-Sun ; Wu, Zhihao ; Song, Yan ; Mitra, Siddhartha S. ; Feroze, Abdullah H. ; Cheshier, Samuel H. ; Lu, Bingwei
刊名	genes development
	2013
关键词	Notch PINK1 mTORC2/AKT signaling mitochondria neural stem cells cancer stem cells PARKINSONS-DISEASE QUALITY-CONTROL SELF-RENEWAL DROSOPHILA CANCER DIVISION GROWTH DIFFERENTIATION MUTATIONS INTERACTS
DOI	10.1101/gad.225169.113
英文摘要	The self-renewal versus differentiation choice of Drosophila and mammalian neural stem cells (NSCs) requires Notch (N) signaling. How N regulates NSC behavior is not well understood. Here we show that canonical N signaling cooperates with a noncanonical N signaling pathway to mediate N-directed NSC regulation. In the noncanonical pathway, N interacts with PTEN-induced kinase 1 (PINK1) to influence mitochondrial function, activating mechanistic target of rapamycin complex 2 (mTORC2)/AKT signaling. Importantly, attenuating noncanonical N signaling preferentially impaired the maintenance of Drosophila and human cancer stem cell-like tumor-forming cells. Our results emphasize the importance of mitochondria to N and NSC biology, with important implications for diseases associated with aberrant N signaling.; Cell Biology; Developmental Biology; Genetics & Heredity; SCI(E); 0; ARTICLE; 24; 2642-2647; 27
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/390759]
专题	生命科学学院
推荐引用方式 GB/T 7714	Lee, Kyu-Sun,Wu, Zhihao,Song, Yan,et al. Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway[J]. genes development,2013.
APA	Lee, Kyu-Sun.,Wu, Zhihao.,Song, Yan.,Mitra, Siddhartha S..,Feroze, Abdullah H..,...&Lu, Bingwei.(2013).Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway.genes development.
MLA	Lee, Kyu-Sun,et al."Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway".genes development (2013).