B cell maturation protein is a receptor for the tumor necrosis factor   family member TALL-1

doi:10.1073/pnas.160213497

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	B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1
	Shu, HB ; Johnson, H
刊名	proceedings of the national academy of sciences of the united states of america
	2000
关键词	NF-KAPPA-B TNF RECEPTOR LIGAND APOPTOSIS SUPERFAMILY ACTIVATION DEATH GROWTH TRAIL IDENTIFICATION
DOI	10.1073/pnas.160213497
英文摘要	TALL-1 is a recently identified member of the tumor necrosis factor (TNF) family that costimulates B lymphocyte proliferation. Here we show that B cell maturation protein (BCMA), a member of the TNF receptor family that is expressed only by B lymphocytes, specifically binds to TALL-1. A soluble receptor containing the extracellular domain of BCMA blocks the binding of TALL-1 to its receptor on the plasma membrane and inhibits TALL-1-triggered B lymphocyte costimulation. Overexpression of BCMA activates NF-kappa B, and this activation is potentiated by TALL-1. Moreover, BCMA-mediated NF-kappa B activation is inhibited by dominant negative mutants of TNF receptor-associated factor 5 (TRAF5), TRAF6, NF-kappa B-inducing kinase (NIK), and I kappa B kinase (IKK). These data indicate that BCMA is a receptor for TALL-1 and BCMA activates NF-kappa B through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of BCMA as a NF-kappa B-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000088608000072&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Multidisciplinary Sciences; SCI(E); 108; ARTICLE; 16; 9156-9161; 97
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/389370]
专题	生命科学学院
推荐引用方式 GB/T 7714	Shu, HB,Johnson, H. B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1[J]. proceedings of the national academy of sciences of the united states of america,2000.
APA	Shu, HB,&Johnson, H.(2000).B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.proceedings of the national academy of sciences of the united states of america.
MLA	Shu, HB,et al."B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1".proceedings of the national academy of sciences of the united states of america (2000).