Intracrine hepatopoietin potentiates AP-1 activity through JAB1   independent of MAPK pathway

doi:10.1096/fj.01-0506fje

CORC > 北京大学 > 生命科学学院

	Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway
	Lu, CR ; Li, Y ; Zhao, YL ; Xing, GC ; Tang, F ; Wang, QM ; Sun, YH ; Wei, HD ; Yang, XM ; Wu, CS ; Chen, JG ; Guan, KL ; Zhang, CG ; Chen, HP ; He, FC
刊名	faseb journal
	2002
关键词	intracellular signaling augmenter of liver regeneration HEPATIC STIMULATOR SUBSTANCE FIBROBLAST-GROWTH-FACTOR LIVER-REGENERATION COP9 SIGNALOSOME PROTEIN GENE KINASE RECEPTOR YEAST TRANSCRIPTION
DOI	10.1096/fj.01-0506fje
英文摘要	Many growth factors and cytokines are involved in liver regeneration. Of them, only hepatopoietin (HPO)/ALR (augmenter of liver regeneration) is a specifically hepatotrophic factor originally identified from the cytosol of regenerating or hyperplastic hepatic cells. Previous reports indicate that extracellular HPO triggers the MAPK pathway by binding its specific receptor on the cell surface. However, its function in the cytosol of hepatocytes is unclear. Here we identified that JAB1 (Jun activation domain-binding protein 1), a co-activator of AP-1, which is essential for liver regeneration, specifically interacts with intracellular HPO. JAB1 colocalizes with HPO in nuclei of hepatic cells or COS-7 cells. As an intracrine factor, the intracellular function of HPO is to increase c-Jun phosphorylation independent of c-Jun amino-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) -1 and -2, and leads to potentiation of JAB1-mediated AP-1 activation. Amino acids 1-63 of HPO molecule are sufficient to bind to JAB1, but the full-length HPO is necessary for its intracellular signaling. Taken together, these results elucidate a novel mechanism of intracrine cytokine signaling by specifically modulating the AP-1 pathway through JAB1, in a MAPK-independent fashion.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000173656600024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Biology; Cell Biology; SCI(E); 52; ARTICLE; 1; 90-92; 16
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/388517]
专题	生命科学学院
推荐引用方式 GB/T 7714	Lu, CR,Li, Y,Zhao, YL,et al. Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway[J]. faseb journal,2002.
APA	Lu, CR.,Li, Y.,Zhao, YL.,Xing, GC.,Tang, F.,...&He, FC.(2002).Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway.faseb journal.
MLA	Lu, CR,et al."Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway".faseb journal (2002).