Two interacting bZIP proteins are direct targets of COP1-mediated   control of light-dependent gene expression in Arabidopsis

doi:10.1101/gad.969702

CORC > 北京大学 > 生命科学学院

	Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis
	Holm, M ; Ma, LG ; Qu, LJ ; Deng, XW
刊名	genes development
	2002
关键词	photomorphogenesis transcription COP1 bZIP Arabidopsis protein degradation PHOTOMORPHOGENIC REPRESSOR COP1 LOOP-HELIX PROTEIN TRANSCRIPTION-FACTOR SIGNAL-TRANSDUCTION REGULATED GENE BHLH PROTEIN PHYTOCHROME HY5 ENCODES THALIANA
DOI	10.1101/gad.969702
英文摘要	Arabidopsis COP1 acts to repress photomorphogenesis in the absence of light. it was shown that in the dark, CON directly interacts with the bZIP transcription factor HY5, a positive regulator of photomorphogenesis, and promotes its proteasome-mediated degradation. Here we identify a novel bZIP protein HYH, as a new target of COP1. We identify a physical and genetic interaction between HYH and COP1 and show that this interaction results in dark-specific degradation of HYH. Genetic analysis indicates that HYH is predominantly involved in blue-light regulation of development and gene expression, and that the function of HYH in part overlaps with that of HY5. The accumulation of HYH protein, not the mRNA, is dependent on the presence of HY5. Our data suggest that HYH and HYS can, respectively, act as heterodimers and homodimers, thus mediating light-regulated expression of overlapping as well as distinct target genes. We propose that COP1 mediates light control of gene expression through targeted degradation of multiple photomorphogenesis-promoting transcription factors in the nucleus.; Cell Biology; Developmental Biology; Genetics & Heredity; SCI(E); 50; ARTICLE; 10; 1247-1259; 16
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/388269]
专题	生命科学学院
推荐引用方式 GB/T 7714	Holm, M,Ma, LG,Qu, LJ,et al. Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis[J]. genes development,2002.
APA	Holm, M,Ma, LG,Qu, LJ,&Deng, XW.(2002).Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis.genes development.
MLA	Holm, M,et al."Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis".genes development (2002).