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	Proteomic analysis of corticobasal degeneration: A case study of corticobasal degeneration at the proteome level
	Chen, W ; Ji, JG ; Ru, BG
	2005
关键词	PROGRESSIVE SUPRANUCLEAR PALSY GEL-ELECTROPHORESIS ALZHEIMERS-DISEASE CARBONYL REDUCTASE REPAIR ENZYME PROTEINS BRAIN METHYLTRANSFERASE IDENTIFICATION OPPORTUNITIES
DOI	10.1176/appi.neuropsych.17.3.364
英文摘要	Corticobasal degeneration (CBD) is an adult-onset progressive neurodegenerative disorder. However, its pathogenic mechanisms underlying this disorder remain poorly understood. The authors examined changes of proteome profiles between three nondemented comparison brains and a CBD brain based on two-dimensional gel electrophoresis. Two up-regulated proteins in the CBD brain were identified as protein-L-isoaspartate (D-aspartate) O-methyltransferase and cofilin 1 (non-muscle), and six down-regulated proteins were identified as carbonyl reductase [NADPH] 1, two of peptidylprolyl cis-trans isomerase A, ubiquitin carboxylterminal hydrolase isozyme L1, phosphoglycerate mutase 1 (brain) and chain A of human peroxiredoxin 5. Subsequently, the possible relevance of these changes was analyzed.; Clinical Neurology; Neurosciences; Psychiatry; SCI(E); PubMed; 6; ARTICLE; 3; 364-371; 17
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/345969]
专题	生命科学学院
推荐引用方式 GB/T 7714	Chen, W,Ji, JG,Ru, BG. Proteomic analysis of corticobasal degeneration: A case study of corticobasal degeneration at the proteome level[J],2005.
APA	Chen, W,Ji, JG,&Ru, BG.(2005).Proteomic analysis of corticobasal degeneration: A case study of corticobasal degeneration at the proteome level..
MLA	Chen, W,et al."Proteomic analysis of corticobasal degeneration: A case study of corticobasal degeneration at the proteome level".(2005).

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