Claudin-6 and claudin-9 function as additional coreceptors for hepatitis   C virus

doi:10.1128/JVI.01457-07

CORC > 北京大学 > 生命科学学院

	Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus
	Zheng, Aihua ; Yuan, Fei ; Li, Yanqin ; Zhu, Fangfang ; Hou, Pingping ; Li, Jianqing ; Song, Xijun ; Ding, Mingxiao ; Deng, Hongkui
刊名	病毒学杂志
	2007
关键词	B TYPE-I HEPATOCELLULAR-CARCINOMA NEUTRALIZING ANTIBODIES VIRAL-INFECTION CELL ENTRY REPLICATION RECEPTOR GENE PROTEIN CD81
DOI	10.1128/JVI.01457-07
英文摘要	Hepatitis C virus (HCV) is a global challenge to public health. Several factors have been proven to be critical for HCV entry, including the newly identified claudin-1 (CLDN1). However, the mechanism of HCV entry is still obscure. Presently, among the 20 members of the claudin family identified in humans so far, CLDN1 has been the only member shown to be necessary for HCV entry. Recently, we discovered that Bel7402, an HCV-permissive cell line, does not express CLDN1 but expresses other members of claudin family. Among these claudins, CLDN9 was able to mediate HCV entry just as efficiently as CLDN1. We then examined if other members of the claudin family could mediate entry. We show that CLDN6 and CLDN9, but not CLDN2, CLDN3, CLDN4, CLDN7, CLDN11, CLDN12, CLDN15, CLDN17, and CLDN23, were able to mediate the entry of HCV into target cells. We found that CLDN6 and CLDN9 are expressed in the liver, the primary site of HCV replication. We also showed that CLDN6 and CLDN9, but not CLDNI, are expressed in peripheral blood mononuclear cells, an additional site of HCV replication. Through sequence comparison and mutagenesis studies, we show that residues N38 and V45 in the first extracellular loop (EL1) of CLDN9 are necessary for HCV entry.; Virology; SCI(E); PubMed; 112; ARTICLE; 22; 12465-12471; 81
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/345442]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zheng, Aihua,Yuan, Fei,Li, Yanqin,et al. Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus[J]. 病毒学杂志,2007.
APA	Zheng, Aihua.,Yuan, Fei.,Li, Yanqin.,Zhu, Fangfang.,Hou, Pingping.,...&Deng, Hongkui.(2007).Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus.病毒学杂志.
MLA	Zheng, Aihua,et al."Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virus".病毒学杂志 (2007).