GPR56 is highly expressed in neural stem cells but downregulated during   differentiation

doi:10.1097/WNR.0b013e32832c92d7

CORC > 北京大学 > 生命科学学院

	GPR56 is highly expressed in neural stem cells but downregulated during differentiation
	Bai, Yun ; Du, Liying ; Shen, Li ; Zhang, Ye ; Zhang, Lijun
刊名	neuroreport
	2009
关键词	differentiation G-protein-coupled receptor 56 nestin neural progenitor cell neural stem cell PROTEIN-COUPLED RECEPTOR GPCR
DOI	10.1097/WNR.0b013e32832c92d7
英文摘要	The G-protein-coupled receptor 56 (GPR56) plays important roles in brain development and tumorigenesis. cDNA data suggest that GPR56 has potential to become a neural stem cell (NSC) or neural progenitor cell (NPC) marker. However, expression of GPR56 protein in human NSC/NPCs was not explored. Using specific antibodies and immunochemistry, we showed that GPR56 was highly expressed in nestin-positive NSC/NPCs in the ventricular/ subventricular zone of human and mouse fetal brains, and in cultured neurospheres derived from both human and mouse fetal brains. Downregulation of GPR56 protein occurred earlier than that of nestin in differentiating neurosphere cultures. Loss of GPR56 protein was also evident in well-differentiated glial fibrillary acidic protein-positive astrocytes and beta III-tubulin-positive neurons. Our data suggest that GPR56 can be used as an NSC/NPC marker within the neural cell lineage, especially in combination with nestin. NeuroReport 20:918-922 (C) 2009 Wolters Kluwer Health \| Lippincott Williams & Wilkins.; Neurosciences; SCI(E); PubMed; 9; ARTICLE; 10; 918-922; 20
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/344956]
专题	生命科学学院
推荐引用方式 GB/T 7714	Bai, Yun,Du, Liying,Shen, Li,et al. GPR56 is highly expressed in neural stem cells but downregulated during differentiation[J]. neuroreport,2009.
APA	Bai, Yun,Du, Liying,Shen, Li,Zhang, Ye,&Zhang, Lijun.(2009).GPR56 is highly expressed in neural stem cells but downregulated during differentiation.neuroreport.
MLA	Bai, Yun,et al."GPR56 is highly expressed in neural stem cells but downregulated during differentiation".neuroreport (2009).