mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C-elegans | |
Liu, Min ; Liu, Pengpeng ; Zhang, Li ; Cai, Qingchun ; Gao, Ge ; Zhang, Wenxia ; Zhu, Zuoyan ; Liu, Dong ; Fan, Qichang | |
刊名 | 细胞研究英文版
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2011 | |
关键词 | miRNA C. elegans mir-35 G1/S transition germ cell proliferation NEMATODE CAENORHABDITIS-ELEGANS DEPENDENT KINASE INHIBITOR RNA-BINDING PROTEIN MESSENGER-RNA DEVELOPMENTAL REGULATION CYCLE PROGRESSION MICRORNA FAMILY MITOTIC REGION LIN-35 RB GENE |
DOI | 10.1038/cr.2011.102 |
英文摘要 | MicroRNA (miRNA) regulates gene expression in many cellular events, yet functions of only a few miRNAs are known in C. elegans. We analyzed the function of mir-35-41 unique to the worm, and show here that mir-35 regulates the G1/S transition of intestinal cells and germ cell proliferation. Loss of mir-35 leads to a decrease of nuclei numbers in intestine and distal mitotic gonad, while re-introduction of mir-35 rescues the mutant phenotypes. Genetic analysis indicates that mir-35 may act through Rb/E2F and SCF pathways. Further bioinformatic and functional analyses demonstrate that mir-35 targets evolutionally conserved lin-23 and gld-1. Together, our study reveals a novel function of mir-35 family in cell division regulation.; Cell Biology; SCI(E); PubMed; 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 6; ARTICLE; 11; 1605-1618; 21 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/343674] ![]() |
专题 | 生命科学学院 |
推荐引用方式 GB/T 7714 | Liu, Min,Liu, Pengpeng,Zhang, Li,et al. mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C-elegans[J]. 细胞研究英文版,2011. |
APA | Liu, Min.,Liu, Pengpeng.,Zhang, Li.,Cai, Qingchun.,Gao, Ge.,...&Fan, Qichang.(2011).mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C-elegans.细胞研究英文版. |
MLA | Liu, Min,et al."mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C-elegans".细胞研究英文版 (2011). |
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