mir-35 is involved in intestine cell G1/S transition and germ cell   proliferation in C-elegans

doi:10.1038/cr.2011.102

CORC > 北京大学 > 生命科学学院

	mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C-elegans
	Liu, Min ; Liu, Pengpeng ; Zhang, Li ; Cai, Qingchun ; Gao, Ge ; Zhang, Wenxia ; Zhu, Zuoyan ; Liu, Dong ; Fan, Qichang
刊名	细胞研究英文版
	2011
关键词	miRNA C. elegans mir-35 G1/S transition germ cell proliferation NEMATODE CAENORHABDITIS-ELEGANS DEPENDENT KINASE INHIBITOR RNA-BINDING PROTEIN MESSENGER-RNA DEVELOPMENTAL REGULATION CYCLE PROGRESSION MICRORNA FAMILY MITOTIC REGION LIN-35 RB GENE
DOI	10.1038/cr.2011.102
英文摘要	MicroRNA (miRNA) regulates gene expression in many cellular events, yet functions of only a few miRNAs are known in C. elegans. We analyzed the function of mir-35-41 unique to the worm, and show here that mir-35 regulates the G1/S transition of intestinal cells and germ cell proliferation. Loss of mir-35 leads to a decrease of nuclei numbers in intestine and distal mitotic gonad, while re-introduction of mir-35 rescues the mutant phenotypes. Genetic analysis indicates that mir-35 may act through Rb/E2F and SCF pathways. Further bioinformatic and functional analyses demonstrate that mir-35 targets evolutionally conserved lin-23 and gld-1. Together, our study reveals a novel function of mir-35 family in cell division regulation.; Cell Biology; SCI(E); PubMed; 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); 6; ARTICLE; 11; 1605-1618; 21
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/343674]
专题	生命科学学院
推荐引用方式 GB/T 7714	Liu, Min,Liu, Pengpeng,Zhang, Li,et al. mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C-elegans[J]. 细胞研究英文版,2011.
APA	Liu, Min.,Liu, Pengpeng.,Zhang, Li.,Cai, Qingchun.,Gao, Ge.,...&Fan, Qichang.(2011).mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C-elegans.细胞研究英文版.
MLA	Liu, Min,et al."mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C-elegans".细胞研究英文版 (2011).