Poly(C)-binding protein 1 (PCBP1) mediates housekeeping degradation of   mitochondrial antiviral signaling (MAVS)

doi:10.1038/cr.2011.184

CORC > 北京大学 > 生命科学学院

	Poly(C)-binding protein 1 (PCBP1) mediates housekeeping degradation of mitochondrial antiviral signaling (MAVS)
	Zhou, Xiang ; You, Fuping ; Chen, Huihui ; Jiang, Zhengfan
刊名	细胞研究英文版
	2012
关键词	cellular antiviral immunity MAVS PCBP1 PCBP2 HEPATITIS-C-VIRUS INTERFERON REGULATORY FACTOR-3 INNATE IMMUNE-RESPONSES KH-DOMAIN PROTEINS I-LIKE RECEPTORS ADAPTER PROTEIN NEGATIVE REGULATION GENE-EXPRESSION RNA IDENTIFICATION
DOI	10.1038/cr.2011.184
英文摘要	Mitochondrial antiviral signaling (MAVS) is a key adaptor in cellular antiviral innate immunity. We previously identified poly(C)-binding protein 2 (PCBP2) as a feedback inhibitor of MAVS that facilitates its degradation after viral infection, but little is known about the regulatory potential of poly(C)-binding protein 1 (PCBP1), which highly resembles PCBP2. Here we report that PCBP1 mediates housekeeping degradation of MAVS using the same mechanism as PCBP2 employs. Overexpression of PCBP1 impairs MAVS-mediated antiviral responses, while knockdown of PCBP1 exerts the opposite effect. The suppression is due to PCBP1-induced MAVS degradation. We observe that PCBP1 and PCBP2 show synergy in MAVS inhibition, but their expression patterns are distinct: PCBP1 is stably and abundantly expressed, while PCBP2 shows low basal expression with rapid induction after infection. Individual knockdown and subcellular fractionation analyses reveal that unlike the postinfection inhibitor PCBP2, PCBP1 continuously eliminates cellular MAVS. Our findings unravel a critical role of PCBP1 in regulating MAVS for both fine-tuning the antiviral immunity and preventing inflammation.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000302351800011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Cell Biology; SCI(E); PubMed; 中国科技核心期刊(ISTIC); 15; ARTICLE; 4; 717-727; 22
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/343586]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhou, Xiang,You, Fuping,Chen, Huihui,et al. Poly(C)-binding protein 1 (PCBP1) mediates housekeeping degradation of mitochondrial antiviral signaling (MAVS)[J]. 细胞研究英文版,2012.
APA	Zhou, Xiang,You, Fuping,Chen, Huihui,&Jiang, Zhengfan.(2012).Poly(C)-binding protein 1 (PCBP1) mediates housekeeping degradation of mitochondrial antiviral signaling (MAVS).细胞研究英文版.
MLA	Zhou, Xiang,et al."Poly(C)-binding protein 1 (PCBP1) mediates housekeeping degradation of mitochondrial antiviral signaling (MAVS)".细胞研究英文版 (2012).