The tau-like protein in silkworm (Bombyx mori) induces microtubule bundle formation

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	The tau-like protein in silkworm (Bombyx mori) induces microtubule bundle formation
	Wang Qiao ; Chen Li ; Chen Liang ; Shen Birong ; Liu Yingying ; Chen Jianguo ; Teng Junlin
刊名	frontiers in bioscience elite edition
	2012
英文摘要	Tau proteins are major microtubule-associated proteins (MAPs), which promote polymerization of tubulin and determine spacings between microtubules in axons of both the central and peripheral nervous systems (CNS and PNS). Here, we cloned and identified a tau-like protein BmTau from silkworm, Bombyx mori (GenBank accession number FJ904935). The coding sequence of BmTau is 723 bases long and encodes an approximate 30 kDa protein. In the C-terminus of BmTau are contained four predicted microtubule-binding domains, which share strong sequence homology to its ortholog in Drosophila melanoganster. Relative real-time PCR analysis showed ubiquitous expression of BmTau in both neurons and non-neural cells, with its mRNA abundantly expressing in brain but significantly less detected in trachea, fat body, and silkgland. Furthermore, immunocytochemical studies in BmN cells transfected with EGFP-BmTau indicated that BmTau functioned as microtubule bundling protein as its orthologues.; PubMed; 0; 998-1008; 4
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/343517]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wang Qiao,Chen Li,Chen Liang,et al. The tau-like protein in silkworm (Bombyx mori) induces microtubule bundle formation[J]. frontiers in bioscience elite edition,2012.
APA	Wang Qiao.,Chen Li.,Chen Liang.,Shen Birong.,Liu Yingying.,...&Teng Junlin.(2012).The tau-like protein in silkworm (Bombyx mori) induces microtubule bundle formation.frontiers in bioscience elite edition.
MLA	Wang Qiao,et al."The tau-like protein in silkworm (Bombyx mori) induces microtubule bundle formation".frontiers in bioscience elite edition (2012).