Structural basis for the autoinhibition of the C-terminal kinase domain   of human RSK1

doi:10.1107/S0907444912007457

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	Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1
	Li, Dan ; Fu, Tian-Min ; Nan, Jie ; Liu, Cong ; Li, Lan-Fen ; Su, Xiao-Dong
刊名	acta crystallographica section d biological crystallography
	2012
关键词	ACTIVATED PROTEIN-KINASE RIBOSOMAL S6 KINASE IN-VIVO INDUCED PHOSPHORYLATION CATALYTIC SUBUNIT MAPK FAMILY IDENTIFICATION GENE CREB
DOI	10.1107/S0907444912007457
英文摘要	p90 ribosomal S6 kinases (RSKs) respond to various mitogen stimuli and comprise two distinct protein kinase domains. The C-terminal kinase domain (CTKD) receives signal from ERK1/2 and adopts an autoinhibitory mechanism. Here, the crystal structure of human RSK1 CTKD is reported at 2.7 angstrom resolution. The structure shows a standard kinase fold, with the catalytic residues in the ATP-binding cleft orientated in optimal conformations for phosphotransfer. The inactivation of the CTKD is conferred by an extra alpha-helix (alpha L), which occupies the substrate-binding groove. In combination with previous knowledge, this structure indicates that activation of RSK1 involves the removal of alpha L from the substrate-binding groove induced by ERK1/2 phosphorylation.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305003700008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemical Research Methods; Biochemistry & Molecular Biology; Biophysics; Crystallography; SCI(E); PubMed; 4; ARTICLE; Pt 6; 680-685; 68
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/343360]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, Dan,Fu, Tian-Min,Nan, Jie,et al. Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1[J]. acta crystallographica section d biological crystallography,2012.
APA	Li, Dan,Fu, Tian-Min,Nan, Jie,Liu, Cong,Li, Lan-Fen,&Su, Xiao-Dong.(2012).Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1.acta crystallographica section d biological crystallography.
MLA	Li, Dan,et al."Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1".acta crystallographica section d biological crystallography (2012).