HDA18 Affects Cell Fate in Arabidopsis Root Epidermis via Histone   Acetylation at Four Kinase Genes

doi:10.1105/tpc.112.107045

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	HDA18 Affects Cell Fate in Arabidopsis Root Epidermis via Histone Acetylation at Four Kinase Genes
	Liu, Cui ; Li, Lin-Chen ; Chen, Wen-Qian ; Chen, Xian ; Xu, Zhi-Hong ; Bai, Shu-Nong
刊名	plant cell
	2013
关键词	RECEPTOR-LIKE KINASE EXPRESSION PATTERNS RPD3/HDA1 FAMILY THALIANA PROTEIN TRANSCRIPTION DEACETYLASES WEREWOLF BACTERIA PROVIDES
DOI	10.1105/tpc.112.107045
英文摘要	The differentiation of hair (H) and non-hair (N) cells in the Arabidopsis thaliana root epidermis is dependent on positional relationships with underlying cortical cells. We previously found that histone acetylation relays positional information and that a mutant altered in the histone deacetylase gene family member HISTONE DEACETYLASE 18 (HDA18) exhibits altered H and N epidermal cell patterning. Here, we report that HDA18 has in vitro histone deacetylase activity and that both mutation and overexpression of HDA18 led to cells at the N position having H fate. The HDA18 protein physically interacted with histones related to a specific group of kinase genes, which are demonstrated in this study to be components of a positional information relay system. Both down-and upregulation of HDA18 increased transcription of the targeted kinase genes. Interestingly, the acetylation levels of histone 3 lysine 9 (H3K9), histone 3 lysine 14 (H3K14) and histone 3 lysine 18 (H3K18) at the kinase genes were differentially affected by down-or upregulation of HDA18, which explains why the transcription levels of the four HDA18-target kinase genes increased in all lines with altered HDA18 expression. Our results reveal the surprisingly complex mechanism by which HDA18 affects cellular patterning in Arabidopsis root epidermis.; Biochemistry & Molecular Biology; Plant Sciences; Cell Biology; SCI(E); PubMed; 11; ARTICLE; 1; 257-269; 25
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/343011]
专题	生命科学学院
推荐引用方式 GB/T 7714	Liu, Cui,Li, Lin-Chen,Chen, Wen-Qian,et al. HDA18 Affects Cell Fate in Arabidopsis Root Epidermis via Histone Acetylation at Four Kinase Genes[J]. plant cell,2013.
APA	Liu, Cui,Li, Lin-Chen,Chen, Wen-Qian,Chen, Xian,Xu, Zhi-Hong,&Bai, Shu-Nong.(2013).HDA18 Affects Cell Fate in Arabidopsis Root Epidermis via Histone Acetylation at Four Kinase Genes.plant cell.
MLA	Liu, Cui,et al."HDA18 Affects Cell Fate in Arabidopsis Root Epidermis via Histone Acetylation at Four Kinase Genes".plant cell (2013).