Region-specific alterations in glutamate receptor 1 phosphorylation   during context-induced drug seeking after withdrawal from morphine   self-administration

doi:10.1097/WNR.0000000000000083

CORC > 北京大学 > 生命科学学院

	Region-specific alterations in glutamate receptor 1 phosphorylation during context-induced drug seeking after withdrawal from morphine self-administration
	Kong, Qingyao ; Song, Dan ; Yu, Long-Chuan
刊名	neuroreport
	2014
关键词	drug-seeking glutamate receptor morphine self-administration phosphorylation withdrawal TIME-DEPENDENT CHANGES NUCLEUS-ACCUMBENS AMPA RECEPTORS GLUR1 SUBUNIT COCAINE INCUBATION HEROIN DOPAMINE BEHAVIOR ERK
DOI	10.1097/WNR.0000000000000083
英文摘要	Re-exposure to morphine-associated environments elicits morphine-seeking behavior after a long period of withdrawal in rats with a history of morphine dependence. Adaptations in glutamate receptor 1 (GluR1) phosphorylation in limbic brain regions have been shown to occur during withdrawal from addictive drugs, such as cocaine, methamphetamine, and heroin. However, whether similar adaptations exist after spontaneous withdrawal from repeated morphine intake has not been studied. In our present study, alterations in GluR1 expression and GluR1 phosphorylation at serine 845 (Ser845) and serine 831 (Ser831) in multiple limbic brain regions of rats were measured following context-induced drug craving after 1 or 10 days of withdrawal from intravenous morphine self-administration. Phosphorylation of GluR1 at Ser845, but not Ser831, increases in the nucleus accumbens and central amygdala from 1 to 10 days of withdrawal, and there were no changes in GluR1 phosphorylation at Ser845 or Ser831 in the hippocampal CA1 subregion from 1 to 10 days of withdrawal. Significant positive correlations between numbers of drug-seeking responses and GluR1 phosphorylation at Ser845 in the nucleus accumbens were found in individual animals. These results suggest that time-dependent and region-specific changes in phosphorylation of GluR1 at Ser845, but not Ser831, are involved in the drug-seeking behavior elicited by re-exposure to the morphine-associated context. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.; Neurosciences; SCI(E); PubMed; 0; ARTICLE; yulc@pku.edu.cn; 2; 127-133; 25
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/342558]
专题	生命科学学院
推荐引用方式 GB/T 7714	Kong, Qingyao,Song, Dan,Yu, Long-Chuan. Region-specific alterations in glutamate receptor 1 phosphorylation during context-induced drug seeking after withdrawal from morphine self-administration[J]. neuroreport,2014.
APA	Kong, Qingyao,Song, Dan,&Yu, Long-Chuan.(2014).Region-specific alterations in glutamate receptor 1 phosphorylation during context-induced drug seeking after withdrawal from morphine self-administration.neuroreport.
MLA	Kong, Qingyao,et al."Region-specific alterations in glutamate receptor 1 phosphorylation during context-induced drug seeking after withdrawal from morphine self-administration".neuroreport (2014).