Converging Evidence Implicates the Abnormal MicroRNA System in Schizophrenia

doi:10.1093/schbul/sbu148

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	Converging Evidence Implicates the Abnormal MicroRNA System in Schizophrenia
	Zhang Fuquan ; Xu Yong ; Shugart Yin Yao ; Yue Weihua ; Qi Guoyang ; Yuan Guozhen ; Cheng Zaohuo ; Yao Jianjun ; Wang Jidong ; Wang Guoqiang ; Cao Hongbao ; Guo Wei ; Zhou Zhenhe ; Wang Zhiqiang ; Tian Lin ; Jin Chunhui ; Yuan Jianmin ; Liu Chenxing ; Zhang Dai
刊名	schizophrenia bulletin
	2015
关键词	early-onset,mRNA,microRNA,rare variants,schizophrenia
DOI	10.1093/schbul/sbu148
英文摘要	Previous findings are inconsistent; yet, converging evidence suggests an association between schizophrenia (SZ) and the impairment of posttranscriptional regulation of brain development through microRNA (miRNA) systems.This study aims to (1) compare the overall frequency of 121 rare variants (RVs) in 59 genes associated with the miRNA system in genome-wide association studies (GWAS)-derived data including 768 SZ cases and 1348 healthy controls and validated in an independent GWAS data including 1802 SZ cases and 1447 controls; (2) profile genome-wide miRNA expression in blood collected from 15 early-onset SZ (EOS) cases and 15 healthy controls; and (3) construct a miRNA-messenger RNA (mRNA) regulatory network using our previous genome-wide mRNA expression data generated from a separate sample of 18 EOS cases and 12 healthy controls.Our findings indicate that: (1) In genes associated with the control of miRNAs, there are approximately 50% more RVs in SZ cases than in controls (P ≤ 2.62E-10); (2) The observed lower miRNA activity in EOS patients compared with the healthy controls suggests that miRNAs are abnormally downregulated; (3) There exists a predicted regulatory network among some downregulated miRNAs and some upregulated mRNAs.Collectively, results from all 3 lines of evidence, suggest that the genetically based dysregulation of miRNA systems undermines miRNAs' inhibitory effects, resulting in the abnormal upregulation of genome transcription in the development of SZ.? The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.; SCI(E); PubMed; SSCI; 0; ARTICLE; daizhang@bjmu.edu.cn; 3; 728-35; 41
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/341586]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang Fuquan,Xu Yong,Shugart Yin Yao,et al. Converging Evidence Implicates the Abnormal MicroRNA System in Schizophrenia[J]. schizophrenia bulletin,2015.
APA	Zhang Fuquan.,Xu Yong.,Shugart Yin Yao.,Yue Weihua.,Qi Guoyang.,...&Zhang Dai.(2015).Converging Evidence Implicates the Abnormal MicroRNA System in Schizophrenia.schizophrenia bulletin.
MLA	Zhang Fuquan,et al."Converging Evidence Implicates the Abnormal MicroRNA System in Schizophrenia".schizophrenia bulletin (2015).