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	Allelic variation in 5-HTTLPR and the effects of citalopram on the emotional neural network
	Ma Yina ; Li Bingfeng ; Wang Chenbo ; Zhang Wenxia ; Rao Yi ; Han Shihui
	2015
DOI	10.1192/bjp.bp.114.150128
英文摘要	Background Selective serotonin reuptake inhibitors (SSRIs), such as citalopram, which selectively block serotonin transporter (5-HTT) activity, are widely used in the treatment of depression and anxiety disorders. Numerous neuroimaging studies have examined the effects of SSRIs on emotional processes. However, there are considerable inter-individual differences in SSRI effect, and a recent meta-analysis further revealed discrepant effects of acute SSRI administration on neural responses to negative emotions in healthy adults. Aims We examined how a variant of the serotonin-transporter polymorphism (5-HTTLPR), which affects the expression and function of 5-HTT, influenced the acute effects of an SSRI (citalopram) on emotion-related brain activity in healthy adults. Method Combining genetic neuroimaging, pharmacological technique and a psychological paradigm of emotion recognition, we scanned the short/short (s/s) and long/long (l/l) variants of 5-HTTLPR during perception of fearful, happy and neutral facial expressions after the acute administration of an SSRI (i.e. 30 mg citalopram administered orally) or placebo administration. Results We found that 5-HTTLPR modulated the acute effects of citalopram on neural responses to negative emotions. Specifically, relative to placebo, citalopram increased amygdala and insula activity in l/l but not s/s homozygotes during perception of fearful faces. Similar analyses of brain activity in response to happy faces did not show any significant effects. Conclusions Our combined pharmacogenetic and functional imaging results provide a neurogenetic mechanism for discrepant acute effects of SSRIs.? The Royal College of Psychiatrists 2015.; SCI(E); PubMed; SSCI; 0; ARTICLE; shan@pku.edu.cn; 5; 385-92; 206
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/341555]
专题	生命科学学院 心理与认知科学学院
推荐引用方式 GB/T 7714	Ma Yina,Li Bingfeng,Wang Chenbo,et al. Allelic variation in 5-HTTLPR and the effects of citalopram on the emotional neural network[J],2015.
APA	Ma Yina,Li Bingfeng,Wang Chenbo,Zhang Wenxia,Rao Yi,&Han Shihui.(2015).Allelic variation in 5-HTTLPR and the effects of citalopram on the emotional neural network..
MLA	Ma Yina,et al."Allelic variation in 5-HTTLPR and the effects of citalopram on the emotional neural network".(2015).

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