Integrative analysis of haplotype-resolved epigenomes across human   tissues

doi:10.1038/nature14217

CORC > 北京大学 > 生命科学学院

	Integrative analysis of haplotype-resolved epigenomes across human tissues
	Leung, Danny ; Jung, Inkyung ; Rajagopal, Nisha ; Schmitt, Anthony ; Selvaraj, Siddarth ; Lee, Ah Young ; Yen, Chia-An ; Lin, Shin ; Lin, Yiing ; Qiu, Yunjiang ; Xie, Wei ; Yue, Feng ; Hariharan, Manoj ; Ray, Pradipta ; Kuan, Samantha ; Edsall, Lee ; Yang, Hongbo ; Chi, Neil C. ; Zhang, Michael Q. ; Ecker, Joseph R. ; Ren, Bing
刊名	nature
	2015
关键词	EMBRYONIC STEM-CELLS GENE-EXPRESSION ENHANCERS GENOME TRANSCRIPTION PROMOTERS LANDSCAPE BRAIN ATLAS STATE
DOI	10.1038/nature14217
英文摘要	Allelic differences between the two homologous chromosomes can affect the propensity of inheritance in humans; however, the extent of such differences in the human genome has yet to be fully explored. Here we delineate allelic chromatin modifications and transcriptomes among a broad set of human tissues, enabled by a chromosome-spanning haplotype reconstruction strategy(1). The resulting large collection of haplotype-resolved epigenomic maps reveals extensive allelic biases in both chromatin state and transcription, which show considerable variation across tissues and between individuals, and allow us to investigate cis-regulatory relationships between genes and their control sequences. Analyses of histone modification maps also uncover intriguing characteristics of cis-regulatory elements and tissue-restricted activities of repetitive elements. The rich data sets described here will enhance our understanding of the mechanisms by which cis-regulatory elements control gene expression programs.; Multidisciplinary Sciences; SCI(E); PubMed; 5; ARTICLE; biren@ucsd.edu; 7539; 350-4; 518
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/341457]
专题	生命科学学院
推荐引用方式 GB/T 7714	Leung, Danny,Jung, Inkyung,Rajagopal, Nisha,et al. Integrative analysis of haplotype-resolved epigenomes across human tissues[J]. nature,2015.
APA	Leung, Danny.,Jung, Inkyung.,Rajagopal, Nisha.,Schmitt, Anthony.,Selvaraj, Siddarth.,...&Ren, Bing.(2015).Integrative analysis of haplotype-resolved epigenomes across human tissues.nature.
MLA	Leung, Danny,et al."Integrative analysis of haplotype-resolved epigenomes across human tissues".nature (2015).