Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR

doi:10.1074/jbc.M114.571182

CORC > 北京大学 > 生命科学学院

	Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR
	Yoon, Jeongheon ; Feng, Xianxum ; Kim, Yong-Soo ; Shin, Dong-Mi ; Hatzi, Katerina ; Wang, Hongsheng ; Morse, Herbert C.
刊名	journal of biological chemistry
	2014
DOI	10.1074/jbc.M114.571182
英文摘要	B cell lymphoma 6 (BCL6) corepressor (BCOR) was discovered as a BCL6-interacting corepressor, but little is known about its other biological activities in normal B cell development and function. Previously, we found that interferon regulatory factor 8 (IRF8), also known as interferon consensus sequence-binding protein, directly targets a large number of genes in germinal center B cells including BCL6. In this study, we screened potential binding partners of IRF8 using a retrovirus-based protein complementation assay screen in a mouse pre-B cell line. We found that IRF8 interacts directly with BCOR and that the ??-helical region of IRF8 and the BCL6 binding domain of BCOR are required for this interaction. In addition, IRF8 protein interacts directly with BCL6. Using an siRNA-mediated IRF8 knockdown mouse B cell lymphoma cell line, we showed that IRF8 represses Bcor and enhances Bcl6 transcription. Taken together, these data suggest that a complex comprising BCOR-BCL6-IRF8 modulates BCL6-associated transcriptional regulation of germinal center B cell function.; SCI(E); EI; 0; 49; 34250-34257; 289
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/327450]
专题	生命科学学院
推荐引用方式 GB/T 7714	Yoon, Jeongheon,Feng, Xianxum,Kim, Yong-Soo,et al. Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR[J]. journal of biological chemistry,2014.
APA	Yoon, Jeongheon.,Feng, Xianxum.,Kim, Yong-Soo.,Shin, Dong-Mi.,Hatzi, Katerina.,...&Morse, Herbert C..(2014).Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR.journal of biological chemistry.
MLA	Yoon, Jeongheon,et al."Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR".journal of biological chemistry (2014).