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	GxE interactions between FOXO genotypes and tea drinking are significantly associated with cognitive disability at advanced ages in China
	Zeng Yi ; Chen Huashuai ; Ni Ting ; Ruan Rongping ; Feng Lei ; Nie Chao ; Cheng Lingguo ; Li Yang ; Tao Wei ; Gu Jun ; Land Kenneth C ; Yashin Anatoli ; Tan Qihua ; Yang Ze ; Bolund Lars ; Yang Huanming ; Hauser Elizabeth ; Willcox D Craig ; Willcox Bradley J ; Tian Xiao-Li ; Vaupel James W
	2015
关键词	Cognitive disability,FOXO genotypes,GxE interactions,Oldest old.,Tea drinking
DOI	10.1093/gerona/glu060
英文摘要	Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+ demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 or FOXO3-292 and tea drinking at around age 60 or at present time were significantly associated with lower risk of cognitive disability at advanced ages. Associations between tea drinking and reduced cognitive disability were much stronger among carriers of the genotypes of FOXO1A-266 or FOXO3-310 or FOXO3-292 compared with noncarriers, and it was reconfirmed by analysis of three-way interactions across FOXO genotypes, tea drinking at around age 60, and at present time. Based on prior findings from animal and human cell models, we postulate that intake of tea compounds may activate FOXO gene expression, which in turn may positively affect cognitive function in the oldest old population. Our empirical findings imply that the health benefits of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles.? The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000353896100004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; SCI(E); PubMed; SSCI; 3; ARTICLE; zengyi68@gmail.com; 4; 426-33; 70
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/323699]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zeng Yi,Chen Huashuai,Ni Ting,et al. GxE interactions between FOXO genotypes and tea drinking are significantly associated with cognitive disability at advanced ages in China[J],2015.
APA	Zeng Yi.,Chen Huashuai.,Ni Ting.,Ruan Rongping.,Feng Lei.,...&Vaupel James W.(2015).GxE interactions between FOXO genotypes and tea drinking are significantly associated with cognitive disability at advanced ages in China..
MLA	Zeng Yi,et al."GxE interactions between FOXO genotypes and tea drinking are significantly associated with cognitive disability at advanced ages in China".(2015).

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