5-HTTLPR Polymorphism Modulates Neural Mechanisms of Negative   Self-Reflection

doi:10.1093/cercor/bht099

CORC > 北京大学 > 生命科学学院

	5-HTTLPR Polymorphism Modulates Neural Mechanisms of Negative Self-Reflection
	Ma, Yina ; Li, Bingfeng ; Wang, Chenbo ; Shi, Zhenhao ; Sun, Yun ; Sheng, Feng ; Zhang, Yifan ; Zhang, Wenxia ; Rao, Yi ; Han, Shihui
刊名	cerebral cortex
	2014
关键词	5-HTTLPR anterior cingulate anterior insula FMRI negative self-schema SEROTONIN TRANSPORTER GENE MAJOR DEPRESSIVE DISORDER MEDIAL PREFRONTAL CORTEX EVENT-RELATED FMRI ANTIDEPRESSANT TREATMENT UNIPOLAR DEPRESSION HARM AVOIDANCE AFFECTIVE COMPONENTS INCREASED AMYGDALA PERSONALITY
DOI	10.1093/cercor/bht099
英文摘要	Cognitive distortion in depression is characterized by enhanced negative thoughts about both environment and oneself. Carriers of a risk allele for depression, that is, the short (s) allele of the serotonin transporter promoter polymorphism (5-HTTLPR), exhibit amygdala hyperresponsiveness to negative environmental stimuli relative to homozygous long variant (l/l). However, the neural correlates of negative self-schema in s allele carriers remain unknown. Using functional MRI, we scanned individuals with s/s or l/l genotype of the 5-HTTLPR during reflection on their own personality traits or a friend's personality traits. We found that relative to l/l carriers, s/s carriers showed stronger distressed feelings and greater activity in the dorsal anterior cingulate (dACC)/dorsal medial prefrontal cortex (dmPFC) and the right anterior insula (AI) during negative self-reflection. The 5-HTTLPR effect on the distressed feelings was mediated by the AI/inferior frontal (IF) activity during negative self-reflection. The dACC/dmPFC activity explained 20% of the variation in harm-avoidance tendency in s/s but not l/l carriers. The genotype effects on distress and brain activity were not observed during reflection on a friend's negative traits. Our findings reveal that 5-HTTLPR polymorphism modulates distressed feelings and brain activities associated with negative self-schema and suggest a potential neurogenetic susceptibility mechanism for depression.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000343407500014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; SCI(E); PubMed; 11; ARTICLE; shan@pku.edu.cn; 9; 2421-2429; 24
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/323379]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Ma, Yina,Li, Bingfeng,Wang, Chenbo,et al. 5-HTTLPR Polymorphism Modulates Neural Mechanisms of Negative Self-Reflection[J]. cerebral cortex,2014.
APA	Ma, Yina.,Li, Bingfeng.,Wang, Chenbo.,Shi, Zhenhao.,Sun, Yun.,...&Han, Shihui.(2014).5-HTTLPR Polymorphism Modulates Neural Mechanisms of Negative Self-Reflection.cerebral cortex.
MLA	Ma, Yina,et al."5-HTTLPR Polymorphism Modulates Neural Mechanisms of Negative Self-Reflection".cerebral cortex (2014).