Co-methylated Genes in Different Adipose Depots of Pig are Associated   with Metabolic, Inflammatory and Immune Processes

doi:10.7150/ijbs.4493

CORC > 北京大学 > 生命科学学院

	Co-methylated Genes in Different Adipose Depots of Pig are Associated with Metabolic, Inflammatory and Immune Processes
	Li, Mingzhou ; Wu, Honglong ; Wang, Tao ; Xia, Yudong ; Jin, Long ; Jiang, Anan ; Zhu, Li ; Chen, Lei ; Li, Ruiqiang ; Li, Xuewei
刊名	international journal of biological sciences
	2012
关键词	pig subcutaneous adipose tissue visceral adipose tissue DNA methylation MeDIP-seq INSULIN-RESISTANCE PERICARDIAL FAT TISSUE OBESITY MODEL ACID
DOI	10.7150/ijbs.4493
英文摘要	It is well established that the metabolic risk factors of obesity and its comorbidities are more attributed to adipose tissue distribution rather than total adipose mass. Since emerging evidence suggests that epigenetic regulation plays an important role in the aetiology of obesity, we conducted a genome-wide methylation analysis on eight different adipose depots of three pig breeds living within comparable environments but displaying distinct fat level using methylated DNA immunoprecipitation sequencing. We aimed to investigate the systematic association between anatomical location-specific DNA methylation status of different adipose depots and obesity-related phenotypes. We show here that compared to subcutaneous adipose tissues which primarily modulate metabolic indicators, visceral adipose tissues and intermuscular adipose tissue, which are the metabolic risk factors of obesity, are primarily associated with impaired inflammatory and immune responses. This study presents epigenetic evidence for functionally relevant methylation differences between different adipose depots.; Biochemistry & Molecular Biology; Biology; SCI(E); 0; ARTICLE; 6; 831-837; 8
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/320218]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, Mingzhou,Wu, Honglong,Wang, Tao,et al. Co-methylated Genes in Different Adipose Depots of Pig are Associated with Metabolic, Inflammatory and Immune Processes[J]. international journal of biological sciences,2012.
APA	Li, Mingzhou.,Wu, Honglong.,Wang, Tao.,Xia, Yudong.,Jin, Long.,...&Li, Xuewei.(2012).Co-methylated Genes in Different Adipose Depots of Pig are Associated with Metabolic, Inflammatory and Immune Processes.international journal of biological sciences.
MLA	Li, Mingzhou,et al."Co-methylated Genes in Different Adipose Depots of Pig are Associated with Metabolic, Inflammatory and Immune Processes".international journal of biological sciences (2012).