The transcription factor Vox represses endoderm development by   interacting with Casanova and Pou2

doi:10.1242/dev.082008

CORC > 北京大学 > 生命科学学院

	The transcription factor Vox represses endoderm development by interacting with Casanova and Pou2
	Zhao, Jue ; Lambert, Guillaume ; Meijer, Annemarie H. ; Rosa, Frederic M.
刊名	development
	2013
关键词	Zebrafish Endoderm Fate Transcription Nodal PROTEIN-INTERACTION NETWORK NODAL-RELATED SIGNALS EMBRYONIC STEM-CELLS EARLY XENOPUS EMBRYO ONE-EYED-PINHEAD HOMEOBOX GENES ORGANIZER FORMATION ZEBRAFISH ENDODERM MESODERM INDUCTION MATERNAL VEGT
DOI	10.1242/dev.082008
英文摘要	Endoderm and mesoderm are both formed upon activation of Nodal signaling but how endoderm differentiates from mesoderm is still poorly explored. The sox-related gene casanova (sox32) acts downstream of the Nodal signal, is essential for endoderm development and requires the co-factor Pou2 (Pou5f1, Oct3, Oct4) in this process. Conversely, BMP signals have been shown to inhibit endoderm development by an as yet unexplained mechanism. In a search for Casanova regulators in zebrafish, we identified two of its binding partners as the transcription factors Pou2 and Vox, a member of the Vent group of proteins also involved in the patterning of the gastrula. In overexpression studies we show that vox and/or Vent group genes inhibit the capacity of Casanova to induce endoderm, even in the presence of its co-factor Pou2, and that Vox acts as a repressor in this process. We further show that vox, but not other members of the Vent group, is essential for defining the proper endodermal domain size at gastrulation. In this process, vox acts downstream of BMPs. Cell fate analysis further shows that Vox plays a key role downstream of BMP signals in regulating the capacity of Nodal to induce endoderm versus mesoderm by modulating the activity of the Casanova/Pou2 regulatory system.; Developmental Biology; SCI(E); 2; ARTICLE; 5; 1090-1099; 140
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/320167]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhao, Jue,Lambert, Guillaume,Meijer, Annemarie H.,et al. The transcription factor Vox represses endoderm development by interacting with Casanova and Pou2[J]. development,2013.
APA	Zhao, Jue,Lambert, Guillaume,Meijer, Annemarie H.,&Rosa, Frederic M..(2013).The transcription factor Vox represses endoderm development by interacting with Casanova and Pou2.development.
MLA	Zhao, Jue,et al."The transcription factor Vox represses endoderm development by interacting with Casanova and Pou2".development (2013).